Human Gene INTS8 (uc003yhb.4) Description and Page Index
Description: Homo sapiens integrator complex subunit 8 (INTS8), transcript variant 1, mRNA. RefSeq Summary (NM_017864): This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]. Transcript (Including UTRs) Position: hg19 chr8:95,835,518-95,892,721 Size: 57,204 Total Exon Count: 27 Strand: + Coding Region Position: hg19 chr8:95,835,660-95,892,462 Size: 56,803 Coding Exon Count: 27
ID:INT8_HUMAN DESCRIPTION: RecName: Full=Integrator complex subunit 8; Short=Int8; AltName: Full=Protein kaonashi-1; FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. SUBUNIT: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Contains 4 TPR repeats. SEQUENCE CAUTION: Sequence=AAH50536.1; Type=Frameshift; Positions=985; Sequence=BAA91238.1; Type=Erroneous initiation; Sequence=BAA91671.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): INTS8 CDC HuGE Published Literature: INTS8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q75QN2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.