Human Gene WDR70 (uc003jkv.3) Description and Page Index
  Description: Homo sapiens WD repeat domain 70 (WDR70), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:37,379,412-37,752,774 Size: 373,363 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr5:37,379,470-37,752,675 Size: 373,206 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:37,379,412-37,752,774)mRNA (may differ from genome)Protein (654 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=WD repeat-containing protein 70;
SIMILARITY: Belongs to the WD repeat GAD-1 family.
SIMILARITY: Contains 7 WD repeats.
SEQUENCE CAUTION: Sequence=CAC21644.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): WDR70
CDC HuGE Published Literature: WDR70
Positive Disease Associations: Body Height , Body Weight , Brain , Magnesium , Tumor Necrosis Factor-alpha
Related Studies:
  1. Body Height
    , , . [PubMed 0]
  2. Body Weight
    , , . [PubMed 0]
  3. Brain
    Sudha Seshadri et al. BMC medical genetics 2007, Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study., BMC medical genetics. [PubMed 17903297]
    Our results suggest that genes associated with clinical neurological disease also have detectable effects on subclinical phenotypes. These hypothesis generating data illustrate the use of an unbiased approach to discover novel pathways that may be involved in brain aging, and could be used to replicate observations made in other studies.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.82 RPKM in Testis
Total median expression: 331.11 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.8058-0.307 Picture PostScript Text
3' UTR -17.7099-0.179 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q9NW82
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Protein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019899 enzyme binding

-  Descriptions from all associated GenBank mRNAs
  AK291179 - Homo sapiens cDNA FLJ76716 complete cds, highly similar to Homo sapiens WD repeat domain 70 (WDR70), mRNA.
BX537655 - Homo sapiens mRNA; cDNA DKFZp686K0290 (from clone DKFZp686K0290).
AL512685 - Homo sapiens mRNA; cDNA DKFZp547K202 (from clone DKFZp547K202).
BC009648 - Homo sapiens WD repeat domain 70, mRNA (cDNA clone MGC:5524 IMAGE:3454326), complete cds.
LF385026 - JP 2014500723-A/192529: Polycomb-Associated Non-Coding RNAs.
BC025315 - Homo sapiens WD repeat domain 70, mRNA (cDNA clone MGC:39311 IMAGE:5458850), complete cds.
AK001095 - Homo sapiens cDNA FLJ10233 fis, clone HEMBB1000266.
MA620603 - JP 2018138019-A/192529: Polycomb-Associated Non-Coding RNAs.
AK310901 - Homo sapiens cDNA, FLJ17943.
LF335953 - JP 2014500723-A/143456: Polycomb-Associated Non-Coding RNAs.
LF335952 - JP 2014500723-A/143455: Polycomb-Associated Non-Coding RNAs.
LF335950 - JP 2014500723-A/143453: Polycomb-Associated Non-Coding RNAs.
LF335947 - JP 2014500723-A/143450: Polycomb-Associated Non-Coding RNAs.
MA571530 - JP 2018138019-A/143456: Polycomb-Associated Non-Coding RNAs.
MA571529 - JP 2018138019-A/143455: Polycomb-Associated Non-Coding RNAs.
MA571527 - JP 2018138019-A/143453: Polycomb-Associated Non-Coding RNAs.
MA571524 - JP 2018138019-A/143450: Polycomb-Associated Non-Coding RNAs.
LF335940 - JP 2014500723-A/143443: Polycomb-Associated Non-Coding RNAs.
MA571517 - JP 2018138019-A/143443: Polycomb-Associated Non-Coding RNAs.
LF335928 - JP 2014500723-A/143431: Polycomb-Associated Non-Coding RNAs.
LF335927 - JP 2014500723-A/143430: Polycomb-Associated Non-Coding RNAs.
LF335919 - JP 2014500723-A/143422: Polycomb-Associated Non-Coding RNAs.
LF335917 - JP 2014500723-A/143420: Polycomb-Associated Non-Coding RNAs.
LF335916 - JP 2014500723-A/143419: Polycomb-Associated Non-Coding RNAs.
MA571505 - JP 2018138019-A/143431: Polycomb-Associated Non-Coding RNAs.
MA571504 - JP 2018138019-A/143430: Polycomb-Associated Non-Coding RNAs.
MA571496 - JP 2018138019-A/143422: Polycomb-Associated Non-Coding RNAs.
MA571494 - JP 2018138019-A/143420: Polycomb-Associated Non-Coding RNAs.
MA571493 - JP 2018138019-A/143419: Polycomb-Associated Non-Coding RNAs.
LF335912 - JP 2014500723-A/143415: Polycomb-Associated Non-Coding RNAs.
JD181151 - Sequence 162175 from Patent EP1572962.
MA571489 - JP 2018138019-A/143415: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_018034, NP_060504, Q9H053, Q9NW82, WDR70_HUMAN
UCSC ID: uc003jkv.3
RefSeq Accession: NM_018034
Protein: Q9NW82 (aka WDR70_HUMAN)
CCDS: CCDS34147.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_018034.2
exon count: 18CDS single in 3' UTR: no RNA size: 2247
ORF size: 1965CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4124.00frame shift in genome: no % Coverage: 94.44
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.