Human Gene MORC2 (uc003aje.1) Description and Page Index
  Description: Homo sapiens MORC family CW-type zinc finger 2 (MORC2), mRNA.
RefSeq Summary (NM_014941): This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].
Transcript (Including UTRs)
   Position: hg19 chr22:31,322,600-31,364,187 Size: 41,588 Total Exon Count: 27 Strand: -
Coding Region
   Position: hg19 chr22:31,322,790-31,346,402 Size: 23,613 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr22:31,322,600-31,364,187)mRNA (may differ from genome)Protein (970 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=MORC family CW-type zinc finger protein 2; AltName: Full=Zinc finger CW-type coiled-coil domain protein 1;
FUNCTION: May act as a transcriptional repressor. Down-regulates CA9 expression.
SUBUNIT: Interacts with HDAC4.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus.
TISSUE SPECIFICITY: Highly expressed in smooth muscle, pancreas and testis.
SIMILARITY: Contains 1 CW-type zinc finger.
SEQUENCE CAUTION: Sequence=AAC12954.1; Type=Erroneous gene model prediction; Sequence=BAA74875.2; Type=Miscellaneous discrepancy; Note=Intron retention;

-  MalaCards Disease Associations
  MalaCards Gene Search: MORC2
Diseases sorted by gene-association score: charcot-marie-tooth disease, axonal, type 2z* (1550), charcot-marie-tooth disease (6), tooth disease (5), charcot-marie-tooth disease, type 2e (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 39.91 RPKM in Testis
Total median expression: 402.53 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -341.921364-0.251 Picture PostScript Text
3' UTR -59.60190-0.314 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003594 - ATPase-like_ATP-bd
IPR011124 - Znf_CW

Pfam Domains:
PF07496 - CW-type Zinc Finger
PF13589 - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

SCOP Domains:
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase

ModBase Predicted Comparative 3D Structure on Q9Y6X9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AL133637 - Homo sapiens mRNA; cDNA DKFZp434J1618 (from clone DKFZp434J1618).
BC019257 - Homo sapiens MORC family CW-type zinc finger 2, mRNA (cDNA clone MGC:1834 IMAGE:3503651), complete cds.
AB020659 - Homo sapiens KIAA0852 mRNA for KIAA0852 protein.
CR456469 - Homo sapiens dJ430N8.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ430N8.1).
BC136782 - Homo sapiens MORC family CW-type zinc finger 2, mRNA (cDNA clone MGC:168395 IMAGE:9020772), complete cds.
CU013019 - Homo sapiens MORC2, mRNA (cDNA clone IMAGE:100000181), complete cds, with stop codon, in Gateway system.
KJ898417 - Synthetic construct Homo sapiens clone ccsbBroadEn_07811 MORC2 gene, encodes complete protein.
AB385391 - Synthetic construct DNA, clone: pF1KA0852, Homo sapiens MORC2 gene for MORC family CW-type zinc finger protein 2, complete cds, without stop codon, in Flexi system.
BC141657 - Synthetic construct Homo sapiens clone IMAGE:100000085, MGC:164705 MORC family CW-type zinc finger 2 (MORC2) mRNA, encodes complete protein.
CU013307 - Homo sapiens MORC2, mRNA (cDNA clone IMAGE:100000085), complete cds, without stop codon, in Gateway system.
JD280683 - Sequence 261707 from Patent EP1572962.
JD533073 - Sequence 514097 from Patent EP1572962.
JD045671 - Sequence 26695 from Patent EP1572962.
JD381118 - Sequence 362142 from Patent EP1572962.
AY236964 - Homo sapiens MORC-like protein mRNA, partial cds.
CU676410 - Synthetic construct Homo sapiens gateway clone IMAGE:100017864 5' read MORC2 mRNA.
JD426618 - Sequence 407642 from Patent EP1572962.
JD396104 - Sequence 377128 from Patent EP1572962.
JD220386 - Sequence 201410 from Patent EP1572962.
JD545012 - Sequence 526036 from Patent EP1572962.
JD545011 - Sequence 526035 from Patent EP1572962.
JD303602 - Sequence 284626 from Patent EP1572962.
JD062934 - Sequence 43958 from Patent EP1572962.
JD348769 - Sequence 329793 from Patent EP1572962.
JD308543 - Sequence 289567 from Patent EP1572962.
JD198279 - Sequence 179303 from Patent EP1572962.
JD492331 - Sequence 473355 from Patent EP1572962.
JD381661 - Sequence 362685 from Patent EP1572962.
JD323399 - Sequence 304423 from Patent EP1572962.
JD041826 - Sequence 22850 from Patent EP1572962.
JD441855 - Sequence 422879 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RNB1, KIAA0852, MORC2_HUMAN, NM_014941, NP_055756, Q9UF28, Q9Y6V2, Q9Y6X9, ZCWCC1
UCSC ID: uc003aje.1
RefSeq Accession: NM_014941
Protein: Q9Y6X9 (aka MORC2_HUMAN)
CCDS: CCDS33636.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014941.1
exon count: 27CDS single in 3' UTR: no RNA size: 4467
ORF size: 2913CDS single in intron: no Alignment % ID: 99.93
txCdsPredict score: 5180.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.