ID:KPSH1_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase H1; EC=22.214.171.124; AltName: Full=Protein serine kinase H1; Short=PSK-H1; FUNCTION: May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activity depends on Ca(2+) concentration. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, cytoskeleton, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes. TISSUE SPECIFICITY: Expressed in all tissues and cell lines tested with the highest level of abundance in testis. PTM: Autophosphorylated on serine residues. PTM: Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur. PTM: Palmitoylated. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PSKH1 CDC HuGE Published Literature: PSKH1 Positive Disease Associations: Cholesterol, HDL Related Studies:
Cholesterol, HDL Tanya M Teslovich et al. Nature 2010, Biological, clinical and population relevance of 95 loci for blood lipids., Nature.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47473 - EF-hand 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P11801
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.