Human Gene BUD13 (uc001ppn.3) Description and Page Index
  Description: Homo sapiens BUD13 homolog (S. cerevisiae) (BUD13), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:116,618,886-116,643,714 Size: 24,829 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr11:116,619,198-116,643,680 Size: 24,483 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:116,618,886-116,643,714)mRNA (may differ from genome)Protein (619 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: BUD13_HUMAN
DESCRIPTION: RecName: Full=BUD13 homolog;
SIMILARITY: Belongs to the CWC26 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): BUD13
CDC HuGE Published Literature: BUD13
Positive Disease Associations: Lipids , Metabolic Syndrome X , triglycerides
Related Studies:
  1. Lipids
    Aldi T Kraja et al. Diabetes 2011, A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium., Diabetes. [PubMed 21386085]
    Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.
  2. Metabolic Syndrome X
    Aldi T Kraja et al. Diabetes 2011, A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium., Diabetes. [PubMed 21386085]
    Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.
  3. Metabolic Syndrome X
    Aldi T Kraja et al. Diabetes 2011, A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium., Diabetes. [PubMed 21386085]
    Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.61 RPKM in Testis
Total median expression: 414.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.5334-0.133 Picture PostScript Text
3' UTR -92.82312-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018609 - Bud13

Pfam Domains:
PF09736 - Pre-mRNA-splicing factor of RES complex

ModBase Predicted Comparative 3D Structure on Q9BRD0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0000398 mRNA splicing, via spliceosome

Cellular Component:
GO:0005634 nucleus
GO:0070274 RES complex


-  Descriptions from all associated GenBank mRNAs
  LF208473 - JP 2014500723-A/15976: Polycomb-Associated Non-Coding RNAs.
AK225164 - Homo sapiens mRNA for hypothetical protein LOC84811 variant, clone: CBR01405.
BC006350 - Homo sapiens BUD13 homolog (S. cerevisiae), mRNA (cDNA clone MGC:13125 IMAGE:4111572), complete cds.
AK057832 - Homo sapiens cDNA FLJ25103 fis, clone CBR01405.
AK289635 - Homo sapiens cDNA FLJ78694 complete cds.
JD292204 - Sequence 273228 from Patent EP1572962.
AK291111 - Homo sapiens cDNA FLJ76180 complete cds.
JD551105 - Sequence 532129 from Patent EP1572962.
JD171886 - Sequence 152910 from Patent EP1572962.
JD562042 - Sequence 543066 from Patent EP1572962.
LF376626 - JP 2014500723-A/184129: Polycomb-Associated Non-Coding RNAs.
JD222977 - Sequence 204001 from Patent EP1572962.
KJ899831 - Synthetic construct Homo sapiens clone ccsbBroadEn_09225 BUD13 gene, encodes complete protein.
DQ892763 - Synthetic construct clone IMAGE:100005393; FLH189458.01X; RZPDo839F0574D BUD13 homolog (yeast) (BUD13) gene, encodes complete protein.
DQ896008 - Synthetic construct Homo sapiens clone IMAGE:100010468; FLH189454.01L; RZPDo839F0564D BUD13 homolog (yeast) (BUD13) gene, encodes complete protein.
LF376625 - JP 2014500723-A/184128: Polycomb-Associated Non-Coding RNAs.
LF376624 - JP 2014500723-A/184127: Polycomb-Associated Non-Coding RNAs.
AK130600 - Homo sapiens cDNA FLJ27090 fis, clone SPL04148.
LF376623 - JP 2014500723-A/184126: Polycomb-Associated Non-Coding RNAs.
LF376622 - JP 2014500723-A/184125: Polycomb-Associated Non-Coding RNAs.
LF376621 - JP 2014500723-A/184124: Polycomb-Associated Non-Coding RNAs.
AK311068 - Homo sapiens cDNA, FLJ18110.
LF376618 - JP 2014500723-A/184121: Polycomb-Associated Non-Coding RNAs.
LF376617 - JP 2014500723-A/184120: Polycomb-Associated Non-Coding RNAs.
JD389314 - Sequence 370338 from Patent EP1572962.
MA444050 - JP 2018138019-A/15976: Polycomb-Associated Non-Coding RNAs.
MA612203 - JP 2018138019-A/184129: Polycomb-Associated Non-Coding RNAs.
MA612202 - JP 2018138019-A/184128: Polycomb-Associated Non-Coding RNAs.
MA612201 - JP 2018138019-A/184127: Polycomb-Associated Non-Coding RNAs.
MA612200 - JP 2018138019-A/184126: Polycomb-Associated Non-Coding RNAs.
MA612199 - JP 2018138019-A/184125: Polycomb-Associated Non-Coding RNAs.
MA612198 - JP 2018138019-A/184124: Polycomb-Associated Non-Coding RNAs.
MA612195 - JP 2018138019-A/184121: Polycomb-Associated Non-Coding RNAs.
MA612194 - JP 2018138019-A/184120: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K0S0, BUD13_HUMAN, NM_032725, NP_116114, Q96LS7, Q9BRD0
UCSC ID: uc001ppn.3
RefSeq Accession: NM_032725
Protein: Q9BRD0 (aka BUD13_HUMAN)
CCDS: CCDS8374.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032725.3
exon count: 10CDS single in 3' UTR: no RNA size: 2216
ORF size: 1860CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3826.00frame shift in genome: no % Coverage: 99.55
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.