Human Gene POLR3C (uc001eoh.3) Description and Page Index
  Description: Homo sapiens polymerase (RNA) III (DNA directed) polypeptide C (62kD) (POLR3C), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:145,592,605-145,610,884 Size: 18,280 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr1:145,592,690-145,609,336 Size: 16,647 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:145,592,605-145,610,884)mRNA (may differ from genome)Protein (534 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: RPC3_HUMAN
DESCRIPTION: RecName: Full=DNA-directed RNA polymerase III subunit RPC3; Short=RNA polymerase III subunit C3; AltName: Full=DNA-directed RNA polymerase III subunit C; AltName: Full=RNA polymerase III 62 kDa subunit; Short=RPC62;
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
SUBUNIT: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
MISCELLANEOUS: Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).
SIMILARITY: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.

-  MalaCards Disease Associations
  MalaCards Gene Search: POLR3C
Diseases sorted by gene-association score: chickenpox (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.80 RPKM in Testis
Total median expression: 363.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.80161-0.409 Picture PostScript Text
3' UTR -23.3085-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013197 - RNA_pol_III_RPC82-rel_HTH
IPR008806 - RNA_pol_III_Rpc82_C

Pfam Domains:
PF05645 - RNA polymerase III subunit RPC82
PF08221 - RNA polymerase III subunit RPC82 helix-turn-helix domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2XUB
- X-ray MuPIT

2XV4
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9BUI4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsemblFlyBaseWormBaseSGD
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
 AlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0001056 RNA polymerase III activity

Biological Process:
GO:0002376 immune system process
GO:0006351 transcription, DNA-templated
GO:0006359 regulation of transcription from RNA polymerase III promoter
GO:0006383 transcription from RNA polymerase III promoter
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC002586 - Homo sapiens polymerase (RNA) III (DNA directed) polypeptide C (62kD), mRNA (cDNA clone MGC:1325 IMAGE:3140741), complete cds.
AK223413 - Homo sapiens mRNA for polymerase (RNA) III (DNA directed) polypeptide C (62kD) variant, clone: FCC109D01.
BC004424 - Homo sapiens polymerase (RNA) III (DNA directed) polypeptide C (62kD), mRNA (cDNA clone MGC:3538 IMAGE:2820818), complete cds.
U93867 - Human RNA polymerase III subunit (RPC62) mRNA, complete cds.
AY091463 - Homo sapiens RNA polymerase III subunit RPC62 mRNA, complete cds.
JD043496 - Sequence 24520 from Patent EP1572962.
JD229390 - Sequence 210414 from Patent EP1572962.
KJ898261 - Synthetic construct Homo sapiens clone ccsbBroadEn_07655 POLR3C gene, encodes complete protein.
AB464047 - Synthetic construct DNA, clone: pF1KB8177, Homo sapiens POLR3C gene for polymerase (RNA) III (DNA directed) polypeptide C, without stop codon, in Flexi system.
JF432112 - Synthetic construct Homo sapiens clone IMAGE:100073251 polymerase (RNA) III (DNA directed) polypeptide C (62kD) (POLR3C) gene, encodes complete protein.
KJ906050 - Synthetic construct Homo sapiens clone ccsbBroadEn_15720 POLR3C gene, encodes complete protein.
CU678718 - Synthetic construct Homo sapiens gateway clone IMAGE:100019277 5' read POLR3C mRNA.
DQ581295 - Homo sapiens piRNA piR-49407, complete sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00230 - Purine metabolism
hsa00240 - Pyrimidine metabolism
hsa01100 - Metabolic pathways
hsa03020 - RNA polymerase
hsa04623 - Cytosolic DNA-sensing pathway

Reactome (by CSHL, EBI, and GO)

Protein Q9BUI4 (Reactome details) participates in the following event(s):

R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex
R-HSA-83803 Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex
R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex
R-HSA-113454 RNA Polymerase III Termination and release of transcribed RNA
R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters
R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters
R-HSA-112152 RNA Polymerase III Promoter Opening at Type 3 Promoters
R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters
R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters
R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters
R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters
R-HSA-112054 RNA Polymerase III Abortive Initiation At Type 3 Open Promoters
R-HSA-112156 RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters
R-HSA-113442 RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites
R-HSA-113446 Initiation of RNA Polymerase III Productive Transcription
R-HSA-113449 RNA Polymerase III Transcriptional Pause at Terminator Sequence
R-HSA-113451 Resumption of RNA Polymerase III Productive Transcription
R-HSA-113705 RNA Polymerase III Productive Transcription
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-76046 RNA Polymerase III Transcription Initiation
R-HSA-74158 RNA Polymerase III Transcription
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-74160 Gene expression (Transcription)
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: NM_006468, NP_006459, O15317, Q9BUI4, Q9Y3R6, RPC3_HUMAN
UCSC ID: uc001eoh.3
RefSeq Accession: NM_006468
Protein: Q9BUI4 (aka RPC3_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006468.6
exon count: 15CDS single in 3' UTR: no RNA size: 1888
ORF size: 1605CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2765.00frame shift in genome: no % Coverage: 98.04
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.