Human Gene MAGEB18 (uc004dbq.2) Description and Page Index
  Description: Homo sapiens melanoma antigen family B, 18 (MAGEB18), mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:26,156,460-26,158,853 Size: 2,394 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chrX:26,157,103-26,158,134 Size: 1,032 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:26,156,460-26,158,853)mRNA (may differ from genome)Protein (343 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Melanoma-associated antigen B18; AltName: Full=MAGE-B18 antigen;
FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
SUBUNIT: Interacts with LNX1.
INTERACTION: Q06547:GABPB1; NbExp=3; IntAct=EBI-741835, EBI-618165; Q8TBB1:LNX1; NbExp=6; IntAct=EBI-741835, EBI-739832; Q15025:TNIP1; NbExp=2; IntAct=EBI-741835, EBI-357849;
SIMILARITY: Contains 1 MAGE domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: MAGEB18
Diseases sorted by gene-association score: melanoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.64 RPKM in Testis
Total median expression: 0.64 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.20187-0.268 Picture PostScript Text
3' UTR -134.70593-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002190 - MAGE
IPR021072 - Melanoma_ass_antigen_N

Pfam Domains:
PF01454 - MAGE family
PF12440 - Melanoma associated antigen family N terminal

ModBase Predicted Comparative 3D Structure on Q96M61
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  BC029525 - Homo sapiens melanoma antigen family B, 18, mRNA (cDNA clone MGC:33889 IMAGE:5297993), complete cds.
AK057361 - Homo sapiens cDNA FLJ32799 fis, clone TESTI2002516, moderately similar to MELANOMA-ASSOCIATED ANTIGEN B1.
AB464619 - Synthetic construct DNA, clone: pF1KB9832, Homo sapiens MAGEB18 gene for melanoma antigen family B, 18, without stop codon, in Flexi system.
JD145791 - Sequence 126815 from Patent EP1572962.
JD275915 - Sequence 256939 from Patent EP1572962.
JD250728 - Sequence 231752 from Patent EP1572962.
JD110796 - Sequence 91820 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: MAGBI_HUMAN, NM_173699, NP_775970, Q96M61
UCSC ID: uc004dbq.2
RefSeq Accession: NM_173699
Protein: Q96M61 (aka MAGBI_HUMAN)
CCDS: CCDS14216.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_173699.3
exon count: 3CDS single in 3' UTR: no RNA size: 1812
ORF size: 1032CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 2186.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.