ID:MTER1_HUMAN DESCRIPTION: RecName: Full=mTERF domain-containing protein 1, mitochondrial; AltName: Full=Mitochondrial transcription termination factor 3; Short=mTERF3; Flags: Precursor; FUNCTION: Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung. DOMAIN: Contains seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape. SIMILARITY: Belongs to the mTERF family. SEQUENCE CAUTION: Sequence=AAD27721.1; Type=Frameshift; Positions=261, 262;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MTERFD1 CDC HuGE Published Literature: MTERFD1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96E29
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.