Human Gene MAD2L1BP (uc003ovu.3) Description and Page Index
  Description: Homo sapiens MAD2L1 binding protein (MAD2L1BP), transcript variant 1, mRNA.
RefSeq Summary (NM_001003690): The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:43,597,279-43,608,688 Size: 11,410 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr6:43,597,487-43,608,270 Size: 10,784 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:43,597,279-43,608,688)mRNA (may differ from genome)Protein (306 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E9PAT7_HUMAN
DESCRIPTION: SubName: Full=MAD2L1-binding protein;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.95 RPKM in Testis
Total median expression: 358.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -89.61208-0.431 Picture PostScript Text
3' UTR -119.56418-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009511 - MAD1/Cdc20-bound-Mad2-bd

Pfam Domains:
PF06581 - Mad1 and Cdc20-bound-Mad2 binding

ModBase Predicted Comparative 3D Structure on E9PAT7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK297172 - Homo sapiens cDNA FLJ56354 complete cds, highly similar to MAD2L1-binding protein.
BC002904 - Homo sapiens MAD2L1 binding protein, mRNA (cDNA clone MGC:11282 IMAGE:3945348), complete cds.
D14811 - Homo sapiens KIAA0110 mRNA, complete cds.
CR456893 - Homo sapiens full open reading frame cDNA clone RZPDo834E0111D for gene MAD2L1BP, MAD2L1 binding protein; complete cds, incl. stopcodon.
AB384438 - Synthetic construct DNA, clone: pF1KA0110, Homo sapiens MAD2L1BP gene for MAD2L1-binding protein, complete cds, without stop codon, in Flexi system.
CU678282 - Synthetic construct Homo sapiens gateway clone IMAGE:100018702 5' read MAD2L1BP mRNA.
HQ447387 - Synthetic construct Homo sapiens clone IMAGE:100070708; CCSB004424_01 MAD2L1 binding protein (MAD2L1BP) gene, encodes complete protein.
KJ892809 - Synthetic construct Homo sapiens clone ccsbBroadEn_02203 MAD2L1BP gene, encodes complete protein.
DQ597054 - Homo sapiens piRNA piR-35120, complete sequence.
DQ579176 - Homo sapiens piRNA piR-47288, complete sequence.
JD377030 - Sequence 358054 from Patent EP1572962.
JD200981 - Sequence 182005 from Patent EP1572962.
JD490032 - Sequence 471056 from Patent EP1572962.
JD232587 - Sequence 213611 from Patent EP1572962.
JD117989 - Sequence 99013 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PAT7, E9PAT7_HUMAN, NM_001003690, NP_001003690
UCSC ID: uc003ovu.3
RefSeq Accession: NM_001003690
Protein: E9PAT7 CCDS: CCDS47431.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001003690.1
exon count: 4CDS single in 3' UTR: no RNA size: 1550
ORF size: 921CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1920.00frame shift in genome: no % Coverage: 99.81
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.