Human Gene TRMT10C (uc003duz.4) Description and Page Index
Description: Homo sapiens tRNA methyltransferase 10 homolog C (S. cerevisiae) (TRMT10C), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_017819): This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.819130.1, SRR1660807.129865.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000309922.7/ ENSP00000312356.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr3:101,280,680-101,285,290 Size: 4,611 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr3:101,283,626-101,284,837 Size: 1,212 Coding Exon Count: 1
ID:MRRP1_HUMAN DESCRIPTION: RecName: Full=Mitochondrial ribonuclease P protein 1; Short=Mitochondrial RNase P protein 1; EC=2.1.1.-; AltName: Full=HBV pre-S2 trans-regulated protein 2; AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 1; AltName: Full=Renal carcinoma antigen NY-REN-49; AltName: Full=tRNA methyltransferase 10 homolog C; Flags: Precursor; FUNCTION: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. SUBUNIT: Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. INTERACTION: Q99714:HSD17B10; NbExp=4; IntAct=EBI-2107046, EBI-79964; SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the RNA methyltransferase TrmD family. TRM10 subfamily. CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator. SEQUENCE CAUTION: Sequence=AAD42877.1; Type=Erroneous initiation; Sequence=AAH35967.2; Type=Erroneous initiation; Sequence=BAA91166.1; Type=Frameshift; Positions=128;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7L0Y3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.