Human Gene TXNDC9 (uc002szz.3) Description and Page Index
  Description: Homo sapiens thioredoxin domain containing 9 (TXNDC9), mRNA.
RefSeq Summary (NM_005783): The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.535210.1, SRR1660807.128754.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264255.8/ ENSP00000264255.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr2:99,935,487-99,952,860 Size: 17,374 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr2:99,936,145-99,949,673 Size: 13,529 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:99,935,487-99,952,860)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: TXND9_HUMAN
DESCRIPTION: RecName: Full=Thioredoxin domain-containing protein 9; AltName: Full=ATP-binding protein associated with cell differentiation; AltName: Full=Protein 1-4;
FUNCTION: Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.
SUBUNIT: Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.
INTERACTION: Q99689:FEZ1; NbExp=2; IntAct=EBI-707554, EBI-396435;
SIMILARITY: Contains 1 thioredoxin domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.56 RPKM in Cells - Transformed fibroblasts
Total median expression: 328.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.60191-0.343 Picture PostScript Text
3' UTR -136.93658-0.208 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012336 - Thioredoxin-like_fold
IPR013766 - Thioredoxin_domain

Pfam Domains:
PF00085 - Thioredoxin

SCOP Domains:
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on O14530
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsemblFlyBaseWormBaseSGD
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
 AlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0045296 cadherin binding
GO:0008479 queuine tRNA-ribosyltransferase activity

Biological Process:
GO:0008150 biological_process
GO:0008616 queuosine biosynthetic process
GO:0045454 cell redox homeostasis

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0030496 midbody


-  Descriptions from all associated GenBank mRNAs
  AK301722 - Homo sapiens cDNA FLJ55148 complete cds, highly similar to Thioredoxin domain-containing protein 9.
JD261183 - Sequence 242207 from Patent EP1572962.
JD419597 - Sequence 400621 from Patent EP1572962.
JD259551 - Sequence 240575 from Patent EP1572962.
BC070183 - Homo sapiens thioredoxin domain containing 9, mRNA (cDNA clone MGC:88164 IMAGE:4551680), complete cds.
BC005968 - Homo sapiens thioredoxin domain containing 9, mRNA (cDNA clone MGC:14620 IMAGE:4073821), complete cds.
AB006679 - Homo sapiens mRNA for ATP binding protein, complete cds.
JD045741 - Sequence 26765 from Patent EP1572962.
AK222616 - Homo sapiens mRNA for ATP binding protein associated with cell differentiation variant, clone: CBL01104.
JD300709 - Sequence 281733 from Patent EP1572962.
JD267907 - Sequence 248931 from Patent EP1572962.
JD437874 - Sequence 418898 from Patent EP1572962.
BC022864 - Homo sapiens thioredoxin domain containing 9, mRNA (cDNA clone MGC:23721 IMAGE:4096526), complete cds.
JD563262 - Sequence 544286 from Patent EP1572962.
JD046218 - Sequence 27242 from Patent EP1572962.
JD433840 - Sequence 414864 from Patent EP1572962.
JD166533 - Sequence 147557 from Patent EP1572962.
LF207421 - JP 2014500723-A/14924: Polycomb-Associated Non-Coding RNAs.
AK313777 - Homo sapiens cDNA, FLJ94384, Homo sapiens ATP binding protein associated with celldifferentiation (APACD), mRNA.
CR456935 - Homo sapiens full open reading frame cDNA clone RZPDo834A0316D for gene APACD, ATP binding protein associated with cell differentiation; complete cds, incl. stopcodon.
KJ892951 - Synthetic construct Homo sapiens clone ccsbBroadEn_02345 TXNDC9 gene, encodes complete protein.
AB451403 - Homo sapiens TXNDC9 mRNA for ATP binding protein associated with cell differentiation, partial cds, clone: FLJ08106AAAF.
LF366074 - JP 2014500723-A/173577: Polycomb-Associated Non-Coding RNAs.
BC024223 - Homo sapiens thioredoxin domain containing 9, mRNA (cDNA clone MGC:23755 IMAGE:4107372), complete cds.
KJ902073 - Synthetic construct Homo sapiens clone ccsbBroadEn_11467 TXNDC9 gene, encodes complete protein.
CU692888 - Synthetic construct Homo sapiens gateway clone IMAGE:100021877 5' read TXNDC9 mRNA.
LF366073 - JP 2014500723-A/173576: Polycomb-Associated Non-Coding RNAs.
JD200704 - Sequence 181728 from Patent EP1572962.
MA601651 - JP 2018138019-A/173577: Polycomb-Associated Non-Coding RNAs.
MA601650 - JP 2018138019-A/173576: Polycomb-Associated Non-Coding RNAs.
MA442998 - JP 2018138019-A/14924: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: APACD, B2R9G8, D3DVI4, NM_005783, NP_005774, O14530, Q53HG4, Q53RV8, Q6NSF5, Q9BRU6, TXND9_HUMAN
UCSC ID: uc002szz.3
RefSeq Accession: NM_005783
Protein: O14530 (aka TXND9_HUMAN or TXN9_HUMAN)
CCDS: CCDS2044.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_005783.3
exon count: 5CDS single in 3' UTR: no RNA size: 1556
ORF size: 681CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1559.00frame shift in genome: no % Coverage: 98.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.