Human Gene PNO1 (uc002seh.3) Description and Page Index
  Description: Homo sapiens partner of NOB1 homolog (S. cerevisiae) (PNO1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:68,385,005-68,403,094 Size: 18,090 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr2:68,385,067-68,401,934 Size: 16,868 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:68,385,005-68,403,094)mRNA (may differ from genome)Protein (252 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RNA-binding protein PNO1;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes.
SIMILARITY: Belongs to the PNO1 family.
SIMILARITY: Contains 1 KH domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.64 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 322.36 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.0062-0.290 Picture PostScript Text
3' UTR -321.411160-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004087 - KH_dom
IPR004088 - KH_dom_type_1

SCOP Domains:
54791 - Eukaryotic type KH-domain (KH-domain type I)

ModBase Predicted Comparative 3D Structure on Q9NRX1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  BC008304 - Homo sapiens partner of NOB1 homolog (S. cerevisiae), mRNA (cDNA clone MGC:15140 IMAGE:3344225), complete cds.
AK291715 - Homo sapiens cDNA FLJ78110 complete cds.
AF349314 - Homo sapiens RNA-binding protein LOC56902 mRNA, complete cds.
AF164799 - Homo sapiens putatative 28 kDa protein mRNA, complete cds.
AK313204 - Homo sapiens cDNA, FLJ93703, highly similar to Homo sapiens putatative 28 kDa protein (LOC56902), mRNA.
KJ894358 - Synthetic construct Homo sapiens clone ccsbBroadEn_03752 PNO1 gene, encodes complete protein.
AK223118 - Homo sapiens mRNA for putatative 28 kDa protein variant, clone: KAT09031.
L48692 - Homo sapiens (clone p5-23-3) mRNA.
AK225641 - Homo sapiens mRNA for putatative 28 kDa protein variant, clone: SPL06468.
BC018152 - Homo sapiens partner of NOB1 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3876517), partial cds.
JD096886 - Sequence 77910 from Patent EP1572962.
JD357510 - Sequence 338534 from Patent EP1572962.
JD394068 - Sequence 375092 from Patent EP1572962.
JD551183 - Sequence 532207 from Patent EP1572962.
JD298975 - Sequence 279999 from Patent EP1572962.
JD072019 - Sequence 53043 from Patent EP1572962.
JD110024 - Sequence 91048 from Patent EP1572962.
JD502123 - Sequence 483147 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NRX1 (Reactome details) participates in the following event(s):

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6Q0, NM_020143, NP_064528, PNO1_HUMAN, Q53G13, Q8WVB8, Q9NRX1
UCSC ID: uc002seh.3
RefSeq Accession: NM_020143
Protein: Q9NRX1 (aka PNO1_HUMAN)
CCDS: CCDS1885.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_020143.2
exon count: 7CDS single in 3' UTR: no RNA size: 1994
ORF size: 759CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1718.00frame shift in genome: no % Coverage: 99.35
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.