Human Gene BMS1 (uc001jaj.3) Description and Page Index
Description: Homo sapiens BMS1 ribosome biogenesis factor (BMS1), mRNA. RefSeq Summary (NM_014753): This gene likely encodes a ribosome assembly protein. A similar protein in yeast functions in 35S-rRNA processing, which includes a series of cleavage steps critical for formation of 40S ribosomes. Related pseudogenes exist on chromosomes 2, 9, 10, 15, 16, and 22.[provided by RefSeq, Mar 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.240369.1, SRR1803611.73866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374518.6/ ENSP00000363642.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr10:43,277,954-43,330,385 Size: 52,432 Total Exon Count: 23 Strand: + Coding Region Position: hg19 chr10:43,279,843-43,326,544 Size: 46,702 Coding Exon Count: 22
ID:BMS1_HUMAN DESCRIPTION: RecName: Full=Ribosome biogenesis protein BMS1 homolog; AltName: Full=Ribosome assembly protein BMS1 homolog; FUNCTION: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity). SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity). SIMILARITY: Belongs to the BMS1/TSR1 family. BMS1 subfamily. SEQUENCE CAUTION: Sequence=BAA11504.2; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14692
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.