Human Gene EEF1AKNMT (uc001ghz.3)
  Description: Homo sapiens methyltransferase like 13 (EEF1AKNMT), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:171,750,761-171,766,856 Size: 16,096 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr1:171,751,108-171,765,896 Size: 14,789 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:171,750,761-171,766,856)mRNA (may differ from genome)Protein (699 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMGIneXtProtOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MET13_HUMAN
DESCRIPTION: RecName: Full=Methyltransferase-like protein 13; EC=2.1.1.-;
SIMILARITY: Belongs to the methyltransferase superfamily.
SEQUENCE CAUTION: Sequence=BAA74882.2; Type=Erroneous initiation; Sequence=BAD97213.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.38 RPKM in Testis
Total median expression: 353.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -123.10347-0.355 Picture PostScript Text
3' UTR -260.53960-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013216 - Methyltransf_11

Pfam Domains:
PF01564 - Spermine/spermidine synthase domain
PF08241 - Methyltransferase domain
PF13649 - Methyltransferase domain
PF13847 - Methyltransferase domain

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q8N6R0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0008152 metabolic process
GO:0032259 methylation


-  Descriptions from all associated GenBank mRNAs
  AK304471 - Homo sapiens cDNA FLJ56024 complete cds.
AK223493 - Homo sapiens mRNA for KIAA0859 protein (Fragment) variant, clone: FCC120A05.
AK291740 - Homo sapiens cDNA FLJ78423 complete cds.
AK027621 - Homo sapiens cDNA FLJ14715 fis, clone NT2RP3001119.
AF132936 - Homo sapiens CGI-01 protein mRNA, complete cds.
AB242174 - Homo sapiens feat mRNA for antiapoptotic protein FEAT, complete cds.
AL049669 - Human gene from PAC 612B18, chromosome 1.
AK027552 - Homo sapiens cDNA FLJ14646 fis, clone NT2RP2001883, highly similar to Homo sapiens CGI-01 protein mRNA.
AB242175 - Homo sapiens feat mRNA for antiapoptotic protein FEAT, complete cds.
JD310616 - Sequence 291640 from Patent EP1572962.
JD541400 - Sequence 522424 from Patent EP1572962.
AB020666 - Homo sapiens KIAA0859 mRNA for KIAA0859 protein.
BC029083 - Homo sapiens methyltransferase like 13, mRNA (cDNA clone MGC:21094 IMAGE:4509086), complete cds.
JD538490 - Sequence 519514 from Patent EP1572962.
AB384020 - Synthetic construct DNA, clone: pF1KSDA0859, Homo sapiens KIAA0859 gene for KIAA0859 protein, complete cds, without stop codon, in Flexi system.
KJ904757 - Synthetic construct Homo sapiens clone ccsbBroadEn_14151 METTL13-like gene, encodes complete protein.
AK027886 - Homo sapiens cDNA FLJ14980 fis, clone Y79AA1000181, highly similar to Homo sapiens CGI-01 protein mRNA.
AK074552 - Homo sapiens cDNA FLJ90071 fis, clone HEMBA1004067.
AK129561 - Homo sapiens cDNA FLJ26050 fis, clone PRS02782.
DQ576381 - Homo sapiens piRNA piR-44493, complete sequence.
AK001172 - Homo sapiens cDNA FLJ10310 fis, clone NT2RM2000322, highly similar to Homo sapiens mRNA for KIAA0859 protein.
BC006814 - Homo sapiens methyltransferase like 13, mRNA (cDNA clone IMAGE:3448012), partial cds.
AK124482 - Homo sapiens cDNA FLJ42491 fis, clone BRACE2033394.
AK094818 - Homo sapiens cDNA FLJ37499 fis, clone BRAWH2016106.
JD511643 - Sequence 492667 from Patent EP1572962.
JD361291 - Sequence 342315 from Patent EP1572962.
JD150998 - Sequence 132022 from Patent EP1572962.
JD432110 - Sequence 413134 from Patent EP1572962.
JD311041 - Sequence 292065 from Patent EP1572962.
JD359760 - Sequence 340784 from Patent EP1572962.
JD324377 - Sequence 305401 from Patent EP1572962.
JD414429 - Sequence 395453 from Patent EP1572962.
JD227358 - Sequence 208382 from Patent EP1572962.
JD327303 - Sequence 308327 from Patent EP1572962.
JD272241 - Sequence 253265 from Patent EP1572962.
JD347620 - Sequence 328644 from Patent EP1572962.
JD349250 - Sequence 330274 from Patent EP1572962.
JD348986 - Sequence 330010 from Patent EP1572962.
JD358786 - Sequence 339810 from Patent EP1572962.
JD358765 - Sequence 339789 from Patent EP1572962.
JD378903 - Sequence 359927 from Patent EP1572962.
JD296209 - Sequence 277233 from Patent EP1572962.
JD472842 - Sequence 453866 from Patent EP1572962.
JD103475 - Sequence 84499 from Patent EP1572962.
JD170931 - Sequence 151955 from Patent EP1572962.
JD503884 - Sequence 484908 from Patent EP1572962.
JD041104 - Sequence 22128 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NFK0, A8K6S5, CGI-01, KIAA0859, MET13_HUMAN, METTL13, NM_015935, NP_055770, O94940, Q53EZ6, Q5TGP9, Q5TGQ0, Q8N2P8, Q8N6R0, Q96J11, Q96SQ0, Q9Y2Z1, Q9Y3M6
UCSC ID: uc001ghz.3
RefSeq Accession: NM_015935
Protein: Q8N6R0 (aka MET13_HUMAN)
CCDS: CCDS1299.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015935.4
exon count: 8CDS single in 3' UTR: no RNA size: 3421
ORF size: 2100CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4307.00frame shift in genome: no % Coverage: 99.59
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 367# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.