Human Gene PMS2P5 (uc003ubl.2) Description and Page Index
  Description: Homo sapiens postmeiotic segregation increased 2 pseudogene 5 (PMS2P5), transcript variant 1, non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr7:74,306,894-74,322,330 Size: 15,437 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr7:74,310,333-74,321,779 Size: 11,447 Coding Exon Count: 6 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:74,306,894-74,322,330)mRNA (may differ from genome)Protein (199 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIPubMedStanford SOURCETreefam

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.22 RPKM in Testis
Total median expression: 119.88 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.50172-0.305 Picture PostScript Text
3' UTR -165.16551-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003594 - ATPase-like_ATP-bd
IPR002099 - DNA_mismatch_repair
IPR014762 - DNA_mismatch_repair_CS

Pfam Domains:
PF07661 - MORN repeat variant
PF13589 - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

SCOP Domains:
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase

ModBase Predicted Comparative 3D Structure on Q15157
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003684 damaged DNA binding
GO:0016887 ATPase activity

Biological Process:
GO:0006298 mismatch repair

Cellular Component:
GO:0005575 cellular_component
GO:0032300 mismatch repair complex

-  Descriptions from all associated GenBank mRNAs
  BC052588 - Homo sapiens postmeiotic segregation increased 2-like 5, mRNA (cDNA clone IMAGE:6255019), partial cds.
BC027480 - Homo sapiens cDNA clone IMAGE:4397924, **** WARNING: chimeric clone ****.
D38436 - Homo sapiens hPMS4 mRNA, partial cds.
D38502 - Homo sapiens PMS4 mRNA (yeast mismatch repair gene PMS1 homologue), partial cds (C-terminal region).
E11277 - Human cDNA encoding mismatch repair-related protein.
AK309660 - Homo sapiens cDNA, FLJ99701.
D38439 - Homo sapiens hPMS7 mRNA, partial cds.
D38501 - Homo sapiens PMS7 mRNA (yeast mismatch repair gene PMS1 homologue), partial cds (C-terminal region).
E11280 - Human cDNA encoding mismatch repair-related protein.
AB528779 - Synthetic construct DNA, clone: pF1KE0244, Homo sapiens PMS2L5 gene for postmeiotic segregation increased 2-like protein 5, without stop codon, in Flexi system.
BC152850 - Synthetic construct Homo sapiens clone IMAGE:100016062, MGC:184207 postmeiotic segregation increased 2-like 5 (PMS2L5) mRNA, encodes complete protein.
JD070874 - Sequence 51898 from Patent EP1572962.
JD447983 - Sequence 429007 from Patent EP1572962.
JD316586 - Sequence 297610 from Patent EP1572962.
JD538559 - Sequence 519583 from Patent EP1572962.
JD538295 - Sequence 519319 from Patent EP1572962.
DQ573916 - Homo sapiens piRNA piR-42028, complete sequence.
JD044060 - Sequence 25084 from Patent EP1572962.
JD175469 - Sequence 156493 from Patent EP1572962.
DQ584291 - Homo sapiens piRNA piR-51403, complete sequence.
DQ577017 - Homo sapiens piRNA piR-45129, complete sequence.
DQ595418 - Homo sapiens piRNA piR-61530, complete sequence.
JD304835 - Sequence 285859 from Patent EP1572962.
JD415816 - Sequence 396840 from Patent EP1572962.
JD256086 - Sequence 237110 from Patent EP1572962.
DQ596866 - Homo sapiens piRNA piR-34932, complete sequence.
JD489553 - Sequence 470577 from Patent EP1572962.
JD525835 - Sequence 506859 from Patent EP1572962.
JD399050 - Sequence 380074 from Patent EP1572962.
DQ586658 - Homo sapiens piRNA piR-53770, complete sequence.
JD311453 - Sequence 292477 from Patent EP1572962.
JD491817 - Sequence 472841 from Patent EP1572962.
JD062864 - Sequence 43888 from Patent EP1572962.
JD299630 - Sequence 280654 from Patent EP1572962.
JD487137 - Sequence 468161 from Patent EP1572962.
JD118182 - Sequence 99206 from Patent EP1572962.
DQ586947 - Homo sapiens piRNA piR-54059, complete sequence.
JD144181 - Sequence 125205 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: hPMS4, NR_027775, PMS2L5, PMS4, Q15157, Q15157_HUMAN
UCSC ID: uc003ubl.2
RefSeq Accession: NR_027775
Protein: Q15157

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NR_027775.1
exon count: 7CDS single in 3' UTR: no RNA size: 1323
ORF size: 600CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 800.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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