Human Gene ZNF451 (uc003pdm.2) Description and Page Index
Description: Homo sapiens zinc finger protein 451 (ZNF451), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr6:56,954,808-57,035,098 Size: 80,291 Total Exon Count: 15 Strand: +
Position: hg19 chr6:56,955,052-57,033,267 Size: 78,216 Coding Exon Count: 15
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 451; AltName: Full=Coactivator for steroid receptors;
FUNCTION: May be involved in transcriptional regulation. Coactivator for steroid receptors. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 11 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH42450.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=AAH58853.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=BAA25502.1; Type=Erroneous initiation; Sequence=BAB21793.1; Type=Erroneous initiation;
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
ModBase Predicted Comparative 3D Structure on Q9Y4E5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AY055204 - Homo sapiens COASTER mRNA, complete cds. BX648081 - Homo sapiens mRNA; cDNA DKFZp686M03226 (from clone DKFZp686M03226). BC098382 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone MGC:104563 IMAGE:5295845), complete cds. AK225806 - Homo sapiens mRNA for zinc finger protein 451 isoform 1 variant, clone: FCC130C12. AB011148 - Homo sapiens KIAA0576 mRNA for KIAA0576 protein. EU832452 - Synthetic construct Homo sapiens clone HAIB:100067481; DKFZo008A1229 zinc finger protein 451 protein (ZNF451) gene, encodes complete protein. EU832534 - Synthetic construct Homo sapiens clone HAIB:100067563; DKFZo004A1230 zinc finger protein 451 protein (ZNF451) gene, encodes complete protein. AB383910 - Synthetic construct DNA, clone: pF1KSDA0576, Homo sapiens ZNF451 gene for zinc finger protein 451, complete cds, without stop codon, in Flexi system. AK075174 - Homo sapiens cDNA FLJ90693 fis, clone PLACE1006515. AK027805 - Homo sapiens cDNA FLJ14899 fis, clone PLACE1005055. JD468776 - Sequence 449800 from Patent EP1572962. BC021712 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone MGC:26701 IMAGE:4821000), complete cds. AK302577 - Homo sapiens cDNA FLJ53246 complete cds, moderately similar to Zinc finger protein 451. JD462641 - Sequence 443665 from Patent EP1572962. JD372997 - Sequence 354021 from Patent EP1572962. CU692390 - Synthetic construct Homo sapiens gateway clone IMAGE:100017849 5' read ZNF451 mRNA. KJ902409 - Synthetic construct Homo sapiens clone ccsbBroadEn_11803 ZNF451 gene, encodes complete protein. BC042450 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone IMAGE:4838029), partial cds. BC058853 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone IMAGE:4838005), partial cds. AK000983 - Homo sapiens cDNA FLJ10121 fis, clone HEMBA1002935, highly similar to Homo sapiens mRNA for KIAA0576 protein. JD281758 - Sequence 262782 from Patent EP1572962. JD350415 - Sequence 331439 from Patent EP1572962. JD315093 - Sequence 296117 from Patent EP1572962. JD040846 - Sequence 21870 from Patent EP1572962. JD081976 - Sequence 63000 from Patent EP1572962. JD090992 - Sequence 72016 from Patent EP1572962. JD532727 - Sequence 513751 from Patent EP1572962. JD453269 - Sequence 434293 from Patent EP1572962. JD237349 - Sequence 218373 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: COASTER, KIAA0576, KIAA1702, NM_001031623, NP_001026794, Q5VVE9, Q5VVF1, Q86YE4, Q8N380, Q8TD15, Q9C0G1, Q9NQM1, Q9Y4E5, uc003pdm.1, ZN451_HUMAN UCSC ID: uc003pdm.2 RefSeq Accession: NM_001031623
(aka ZN451_HUMAN or Z451_HUMAN) Q9Y4E5
CCDS: CCDS4960.1, CCDS43477.1
Gene Model Information
15 CDS single in 3' UTR:
3186 CDS single in intron:
Alignment % ID:
6572.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
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Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.