Human Gene ZNF451 (uc003pdm.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 451 (ZNF451), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:56,954,808-57,035,098 Size: 80,291 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr6:56,955,052-57,033,267 Size: 78,216 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:56,954,808-57,035,098)mRNA (may differ from genome)Protein (1061 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 451; AltName: Full=Coactivator for steroid receptors;
FUNCTION: May be involved in transcriptional regulation. Coactivator for steroid receptors.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH42450.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=AAH58853.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=BAA25502.1; Type=Erroneous initiation; Sequence=BAB21793.1; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF451
Diseases sorted by gene-association score: peroneal neuropathy (16), brown-sequard syndrome (16), carotid artery dissection (11), benign paroxysmal positional nystagmus (9)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.03 RPKM in Testis
Total median expression: 146.09 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -119.70244-0.491 Picture PostScript Text
3' UTR -423.921831-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

ModBase Predicted Comparative 3D Structure on Q9Y4E5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061665 SUMO ligase activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016925 protein sumoylation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter
GO:2000616 negative regulation of histone H3-K9 acetylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016605 PML body

-  Descriptions from all associated GenBank mRNAs
  AY055204 - Homo sapiens COASTER mRNA, complete cds.
BX648081 - Homo sapiens mRNA; cDNA DKFZp686M03226 (from clone DKFZp686M03226).
BC098382 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone MGC:104563 IMAGE:5295845), complete cds.
AK225806 - Homo sapiens mRNA for zinc finger protein 451 isoform 1 variant, clone: FCC130C12.
AB011148 - Homo sapiens KIAA0576 mRNA for KIAA0576 protein.
EU832452 - Synthetic construct Homo sapiens clone HAIB:100067481; DKFZo008A1229 zinc finger protein 451 protein (ZNF451) gene, encodes complete protein.
EU832534 - Synthetic construct Homo sapiens clone HAIB:100067563; DKFZo004A1230 zinc finger protein 451 protein (ZNF451) gene, encodes complete protein.
AB383910 - Synthetic construct DNA, clone: pF1KSDA0576, Homo sapiens ZNF451 gene for zinc finger protein 451, complete cds, without stop codon, in Flexi system.
AK075174 - Homo sapiens cDNA FLJ90693 fis, clone PLACE1006515.
AK027805 - Homo sapiens cDNA FLJ14899 fis, clone PLACE1005055.
JD468776 - Sequence 449800 from Patent EP1572962.
BC021712 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone MGC:26701 IMAGE:4821000), complete cds.
AK302577 - Homo sapiens cDNA FLJ53246 complete cds, moderately similar to Zinc finger protein 451.
JD462641 - Sequence 443665 from Patent EP1572962.
JD372997 - Sequence 354021 from Patent EP1572962.
CU692390 - Synthetic construct Homo sapiens gateway clone IMAGE:100017849 5' read ZNF451 mRNA.
KJ902409 - Synthetic construct Homo sapiens clone ccsbBroadEn_11803 ZNF451 gene, encodes complete protein.
BC042450 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone IMAGE:4838029), partial cds.
BC058853 - Homo sapiens zinc finger protein 451, mRNA (cDNA clone IMAGE:4838005), partial cds.
AK000983 - Homo sapiens cDNA FLJ10121 fis, clone HEMBA1002935, highly similar to Homo sapiens mRNA for KIAA0576 protein.
JD281758 - Sequence 262782 from Patent EP1572962.
JD350415 - Sequence 331439 from Patent EP1572962.
JD315093 - Sequence 296117 from Patent EP1572962.
JD040846 - Sequence 21870 from Patent EP1572962.
JD081976 - Sequence 63000 from Patent EP1572962.
JD090992 - Sequence 72016 from Patent EP1572962.
JD532727 - Sequence 513751 from Patent EP1572962.
JD453269 - Sequence 434293 from Patent EP1572962.
JD237349 - Sequence 218373 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: COASTER, KIAA0576, KIAA1702, NM_001031623, NP_001026794, Q5VVE9, Q5VVF1, Q86YE4, Q8N380, Q8TD15, Q9C0G1, Q9NQM1, Q9Y4E5, uc003pdm.1, ZN451_HUMAN
UCSC ID: uc003pdm.2
RefSeq Accession: NM_001031623
Protein: Q9Y4E5 (aka ZN451_HUMAN or Z451_HUMAN)
CCDS: CCDS4960.1, CCDS43477.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001031623.2
exon count: 15CDS single in 3' UTR: no RNA size: 5241
ORF size: 3186CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6572.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.