Human Gene ADAM8 (uc021qbe.1) Description and Page Index
Description: Homo sapiens ADAM metallopeptidase domain 8 (ADAM8), transcript variant 1, mRNA.
RefSeq Summary (NM_001109): This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009].
Transcript (Including UTRs)
Position: hg19 chr10:135,075,920-135,090,407 Size: 14,488 Total Exon Count: 23 Strand: -
Position: hg19 chr10:135,076,660-135,090,321 Size: 13,662 Coding Exon Count: 23
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Disintegrin and metalloproteinase domain-containing protein 8; Short=ADAM 8; EC=3.4.24.-; AltName: Full=Cell surface antigen MS2; AltName: CD_antigen=CD156a; Flags: Precursor;
FUNCTION: Possible involvement in extravasation of leukocytes. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Interacts with FST3. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed on neutrophils and monocytes. SIMILARITY: Contains 1 disintegrin domain. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 peptidase M12B domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
ADAM8 CDC HuGE Published Literature:
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006586 - ADAM_Cys-rich
IPR001762 - Blood-coag_inhib_Disintegrin
IPR018358 - Disintegrin_CS
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR024079 - MetalloPept_cat_dom
IPR001590 - Peptidase_M12B
IPR002870 - Peptidase_M12B_N
Pfam Domains: PF00200 - Disintegrin
PF01421 - Reprolysin (M12B) family zinc metalloprotease
PF01562 - Reprolysin family propeptide
PF08516 - ADAM cysteine-rich
PF13574 - Metallo-peptidase family M12B Reprolysin-like
PF13582 - Metallo-peptidase family M12B Reprolysin-like
PF13583 - Metallo-peptidase family M12B Reprolysin-like
PF13688 - Metallo-peptidase family M12
SCOP Domains: 55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin)
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P78325
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF207952 - JP 2014500723-A/15455: Polycomb-Associated Non-Coding RNAs. D26579 - Homo sapiens mRNA for transmembrane protein, complete cds. BC064500 - Homo sapiens ADAM metallopeptidase domain 8, mRNA (cDNA clone IMAGE:6247789). JD549673 - Sequence 530697 from Patent EP1572962. JD514376 - Sequence 495400 from Patent EP1572962. JD111894 - Sequence 92918 from Patent EP1572962. JD078649 - Sequence 59673 from Patent EP1572962. JD067515 - Sequence 48539 from Patent EP1572962. JD198248 - Sequence 179272 from Patent EP1572962. JD415531 - Sequence 396555 from Patent EP1572962. JD191445 - Sequence 172469 from Patent EP1572962. JD335878 - Sequence 316902 from Patent EP1572962. JD473709 - Sequence 454733 from Patent EP1572962. JD473708 - Sequence 454732 from Patent EP1572962. JD387862 - Sequence 368886 from Patent EP1572962. JD144801 - Sequence 125825 from Patent EP1572962. JD275872 - Sequence 256896 from Patent EP1572962. JD189015 - Sequence 170039 from Patent EP1572962. AK301147 - Homo sapiens cDNA FLJ50704 complete cds, highly similar to ADAM 8 precursor (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8). BC115404 - Homo sapiens ADAM metallopeptidase domain 8, mRNA (cDNA clone MGC:134985 IMAGE:40075505), complete cds. JD487401 - Sequence 468425 from Patent EP1572962. JD440511 - Sequence 421535 from Patent EP1572962. JD186219 - Sequence 167243 from Patent EP1572962. JD103597 - Sequence 84621 from Patent EP1572962. AK312834 - Homo sapiens cDNA, FLJ93272, highly similar to Homo sapiens a disintegrin and metalloproteinase domain 8 (ADAM8),mRNA. LF370469 - JP 2014500723-A/177972: Polycomb-Associated Non-Coding RNAs. LF370470 - JP 2014500723-A/177973: Polycomb-Associated Non-Coding RNAs. LF370471 - JP 2014500723-A/177974: Polycomb-Associated Non-Coding RNAs. LF370472 - JP 2014500723-A/177975: Polycomb-Associated Non-Coding RNAs. LF370473 - JP 2014500723-A/177976: Polycomb-Associated Non-Coding RNAs. LF370474 - JP 2014500723-A/177977: Polycomb-Associated Non-Coding RNAs. AX810718 - Sequence 42 from Patent EP1333092. AK304324 - Homo sapiens cDNA FLJ52194 complete cds, highly similar to ADAM 8 precursor (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8). AX810699 - Sequence 23 from Patent EP1333092. AK310662 - Homo sapiens cDNA, FLJ17704. MA403320 - JP 2018130113-A/1: Method, kit for testing chronic myelogenous leukemia (CML), method for isolating CML cells which is resistant to tyrosine kinase inhibitor (TKI), and TKI-resistance reducing agent and screening method thereof. MA403369 - JP 2018130113-A/50: Method, kit for testing chronic myelogenous leukemia (CML), method for isolating CML cells which is resistant to tyrosine kinase inhibitor (TKI), and TKI-resistance reducing agent and screening method thereof. MA403368 - JP 2018130113-A/49: Method, kit for testing chronic myelogenous leukemia (CML), method for isolating CML cells which is resistant to tyrosine kinase inhibitor (TKI), and TKI-resistance reducing agent and screening method thereof. MA606046 - JP 2018138019-A/177972: Polycomb-Associated Non-Coding RNAs. MA606047 - JP 2018138019-A/177973: Polycomb-Associated Non-Coding RNAs. MA606048 - JP 2018138019-A/177974: Polycomb-Associated Non-Coding RNAs. MA606049 - JP 2018138019-A/177975: Polycomb-Associated Non-Coding RNAs. MA606050 - JP 2018138019-A/177976: Polycomb-Associated Non-Coding RNAs. MA606051 - JP 2018138019-A/177977: Polycomb-Associated Non-Coding RNAs. MA443529 - JP 2018138019-A/15455: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ADAM8_HUMAN, H0YLR0, MS2, NM_001109, NP_001100, P78325 UCSC ID: uc021qbe.1 RefSeq Accession: NM_001109
(aka ADAM8_HUMAN or AD08_HUMAN) P78325
Gene Model Information
23 CDS single in 3' UTR:
2475 CDS single in intron:
Alignment % ID:
5147.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
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Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.