Human Gene SLA (uc011ljd.2) Description and Page Index
  Description: Homo sapiens Src-like-adaptor (SLA), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:134,048,973-134,072,603 Size: 23,631 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr8:134,050,769-134,072,525 Size: 21,757 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:134,048,973-134,072,603)mRNA (may differ from genome)Protein (316 aa)
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Wikipedia

-  Comments and Description Text from UniProtKB
  ID: SLAP1_HUMAN
DESCRIPTION: RecName: Full=Src-like-adapter; AltName: Full=Src-like-adapter protein 1; Short=SLAP-1; Short=hSLAP;
FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
SUBUNIT: Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Endosome (By similarity). Note=Colocalizes with endosomes (By similarity).
TISSUE SPECIFICITY: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
INDUCTION: By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.
DOMAIN: The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 1 SH3 domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLA
CDC HuGE Published Literature: SLA
Positive Disease Associations: Blood Viscosity
Related Studies:
  1. Blood Viscosity
    Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903294]
    Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 72.10 RPKM in Whole Blood
Total median expression: 242.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.3578-0.081 Picture PostScript Text
3' UTR -599.871796-0.334 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000980 - SH2
IPR001452 - SH3_domain

Pfam Domains:
PF00017 - SH2 domain
PF00018 - SH3 domain

SCOP Domains:
50044 - SH3-domain
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2CUD
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q13239
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005102 receptor binding
GO:0005515 protein binding

Biological Process:
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009966 regulation of signal transduction
GO:0009967 positive regulation of signal transduction
GO:0016477 cell migration
GO:0030154 cell differentiation
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response

Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BX648382 - Homo sapiens mRNA; cDNA DKFZp686B11205 (from clone DKFZp686B11205).
U44403 - Human Src-like adapter protein mRNA, complete cds.
AK297519 - Homo sapiens cDNA FLJ59930 complete cds, highly similar to SRC-like-adapter.
AK297423 - Homo sapiens cDNA FLJ50391 complete cds, highly similar to SRC-like-adapter.
U30473 - Homo sapiens src-like adapter protein (SLAP) mRNA, complete cds.
AK312584 - Homo sapiens cDNA, FLJ92959, Homo sapiens Src-like-adaptor (SLA), mRNA.
AK310092 - Homo sapiens cDNA, FLJ17134.
AK311010 - Homo sapiens cDNA, FLJ18052.
AK309401 - Homo sapiens cDNA, FLJ99442.
AK310115 - Homo sapiens cDNA, FLJ17157.
AJ238591 - Homo sapiens mRNA for Src-like adaptor protein (SLAP).
AK310108 - Homo sapiens cDNA, FLJ17150.
D89077 - Homo sapiens mRNA for Src-like adapter protein, complete cds.
JD176790 - Sequence 157814 from Patent EP1572962.
JD361067 - Sequence 342091 from Patent EP1572962.
JD137137 - Sequence 118161 from Patent EP1572962.
JD412081 - Sequence 393105 from Patent EP1572962.
JD130436 - Sequence 111460 from Patent EP1572962.
JD349078 - Sequence 330102 from Patent EP1572962.
JD225987 - Sequence 207011 from Patent EP1572962.
JD050047 - Sequence 31071 from Patent EP1572962.
JD043483 - Sequence 24507 from Patent EP1572962.
JD042480 - Sequence 23504 from Patent EP1572962.
JD438354 - Sequence 419378 from Patent EP1572962.
JD328660 - Sequence 309684 from Patent EP1572962.
BC007042 - Homo sapiens Src-like-adaptor, mRNA (cDNA clone MGC:12434 IMAGE:3838933), complete cds.
JD435772 - Sequence 416796 from Patent EP1572962.
JD319765 - Sequence 300789 from Patent EP1572962.
JD102566 - Sequence 83590 from Patent EP1572962.
JD368960 - Sequence 349984 from Patent EP1572962.
JD416823 - Sequence 397847 from Patent EP1572962.
JD109669 - Sequence 90693 from Patent EP1572962.
JD546036 - Sequence 527060 from Patent EP1572962.
JD426907 - Sequence 407931 from Patent EP1572962.
JD310377 - Sequence 291401 from Patent EP1572962.
JD362289 - Sequence 343313 from Patent EP1572962.
JD060199 - Sequence 41223 from Patent EP1572962.
JD167876 - Sequence 148900 from Patent EP1572962.
JD249396 - Sequence 230420 from Patent EP1572962.
JD315020 - Sequence 296044 from Patent EP1572962.
JD309923 - Sequence 290947 from Patent EP1572962.
JD038788 - Sequence 19812 from Patent EP1572962.
JD103036 - Sequence 84060 from Patent EP1572962.
KJ897559 - Synthetic construct Homo sapiens clone ccsbBroadEn_06953 SLA gene, encodes complete protein.
BT019994 - Homo sapiens Src-like-adaptor mRNA, complete cds.
CR536537 - Homo sapiens full open reading frame cDNA clone RZPDo834F0420D for gene SLA, Src-like-adaptor; complete cds, incl. stopcodon.
EU831422 - Synthetic construct Homo sapiens clone HAIB:100066451; DKFZo008B0917 Src-like-adaptor protein (SLA) gene, encodes complete protein.
EU831515 - Synthetic construct Homo sapiens clone HAIB:100066544; DKFZo004B0918 Src-like-adaptor protein (SLA) gene, encodes complete protein.
AB464247 - Synthetic construct DNA, clone: pF1KB6393, Homo sapiens SLA gene for Src-like-adaptor, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_006748, NP_006739, Q13239, Q9UMQ8, SLAP, SLAP1, SLAP1_HUMAN
UCSC ID: uc011ljd.2
RefSeq Accession: NM_006748
Protein: Q13239 (aka SLAP1_HUMAN)
CCDS: CCDS47923.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006748.3
exon count: 7CDS single in 3' UTR: no RNA size: 2872
ORF size: 951CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2092.00frame shift in genome: no % Coverage: 98.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 158# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.