Description: Homo sapiens docking protein 2, 56kDa (DOK2), mRNA. RefSeq Summary (NM_003974): The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr8:21,766,384-21,771,205 Size: 4,822 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr8:21,766,822-21,771,112 Size: 4,291 Coding Exon Count: 5
ID:DOK2_HUMAN DESCRIPTION: RecName: Full=Docking protein 2; AltName: Full=Downstream of tyrosine kinase 2; AltName: Full=p56(dok-2); FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). SUBUNIT: Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. DOMAIN: PTB domain mediates receptor interaction. PTM: On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity). SIMILARITY: Belongs to the DOK family. Type A subfamily. SIMILARITY: Contains 1 IRS-type PTB domain. SIMILARITY: Contains 1 PH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60496
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005057 signal transducer activity, downstream of receptor GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity GO:0005515 protein binding
Biological Process: GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007265 Ras protein signal transduction GO:0007411 axon guidance GO:0050900 leukocyte migration
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