Human Gene CYTH4 (uc003arf.3) Description and Page Index
Description: Homo sapiens cytohesin 4 (CYTH4), mRNA. RefSeq Summary (NM_013385): This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr22:37,678,495-37,711,389 Size: 32,895 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr22:37,678,611-37,709,552 Size: 30,942 Coding Exon Count: 13
ID:CYH4_HUMAN DESCRIPTION: RecName: Full=Cytohesin-4; AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 4; FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP. SUBCELLULAR LOCATION: Cell membrane. TISSUE SPECIFICITY: Expressed predominantly in peripheral blood leukocytes. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SEC7 domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CYTH4 CDC HuGE Published Literature: CYTH4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UIA0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.