Human Gene PLAUR (uc002oxf.2) Description and Page Index
  Description: Homo sapiens plasminogen activator, urokinase receptor (PLAUR), transcript variant 1, mRNA.
RefSeq Summary (NM_002659): This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr19:44,152,723-44,174,498 Size: 21,776 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr19:44,153,042-44,174,272 Size: 21,231 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:44,152,723-44,174,498)mRNA (may differ from genome)Protein (335 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDHuman Cortex Gene ExpressionLynx
MGIneXtProtOMIMPubMedReactomeStanford SOURCE
TreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: UPAR_HUMAN
DESCRIPTION: RecName: Full=Urokinase plasminogen activator surface receptor; Short=U-PAR; Short=uPAR; AltName: Full=Monocyte activation antigen Mo3; AltName: CD_antigen=CD87; Flags: Precursor;
FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
SUBUNIT: Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.
SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable).
TISSUE SPECIFICITY: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
SIMILARITY: Contains 3 UPAR/Ly6 domains.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/plaur/";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PLAUR
CDC HuGE Published Literature: PLAUR
Positive Disease Associations: Forced Expiratory Volume , Scleroderma, Systemic|Systemic Scleroderma|Vascular Diseases , Stroke , Waist-Hip Ratio
Related Studies:
  1. Forced Expiratory Volume
    , , . [PubMed 0]
  2. Scleroderma, Systemic|Systemic Scleroderma|Vascular Diseases
    Manetti M et al. 2011, A genetic variation located in the promoter of the uPAR (CD87) gene is associated with the vascular complications of systemic sclerosis., Arthritis and rheumatism 63(1) : 247-56 2011. [PubMed 20967855]
    The UPAR rs344781 gene variant is associated with the SSc vascular phenotype.
  3. Stroke
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: PLAUR
Diseases sorted by gene-association score: ureter cancer (28), perforated corneal ulcer (15), meleda disease (12), paroxysmal nocturnal hemoglobinuria (10), lipodermatosclerosis (10), lymph node cancer (8), hemoglobinuria (7), paranasal sinus disease (7), pemphigus (7), angiomatous meningioma (6), diphtheria (6), focal segmental glomerulosclerosis (5), colorectal cancer (5), juxtacortical osteosarcoma (5), peripheral osteosarcoma (4), meninges hemangiopericytoma (4), breast cancer (3), lung cancer (3), ovarian cancer, somatic (2), brain cancer (2), prostate cancer (2), bladder cancer, somatic (1), malaria (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.30 RPKM in Whole Blood
Total median expression: 207.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.30226-0.408 Picture PostScript Text
3' UTR -92.00319-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018363 - CD59_antigen_CS
IPR016054 - LY6_UPA_recep-like
IPR001526 - LY6_UPAR

Pfam Domains:
PF00021 - u-PAR/Ly-6 domain

SCOP Domains:
57302 - Snake toxin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1YWH
- X-ray MuPIT

2FD6
- X-ray MuPIT

2I9B
- X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
3BT1 - X-ray MuPIT 3BT2 - X-ray MuPIT 3U73 - X-ray MuPIT
3U74 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q03405
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030377 urokinase plasminogen activator receptor activity
GO:0038023 signaling receptor activity

Biological Process:
GO:0001934 positive regulation of protein phosphorylation
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0030162 regulation of proteolysis
GO:0038195 urokinase plasminogen activator signaling pathway
GO:0042730 fibrinolysis
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043388 positive regulation of DNA binding
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019898 extrinsic component of membrane
GO:0030054 cell junction
GO:0031225 anchored component of membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0071438 invadopodium membrane


-  Descriptions from all associated GenBank mRNAs
  LQ270822 - Sequence 150 from Patent WO2016071350.
X74039 - H.sapiens mRNA for urokinase plasminogen activator receptor.
CR456952 - Homo sapiens full open reading frame cDNA clone RZPDo834C0319D for gene PLAUR, plasminogen activator, urokinase receptor; complete cds, incl. stopcodon.
LQ270826 - Sequence 154 from Patent WO2016071350.
LQ270824 - Sequence 152 from Patent WO2016071350.
LQ270828 - Sequence 156 from Patent WO2016071350.
A18757 - u-PA receptor.
X51675 - H.sapiens urokinase plasminogen activator surface receptor (uPAR) mRNA.
U08839 - Human urokinase-type plasminogen activator receptor mRNA, complete cds.
AK290774 - Homo sapiens cDNA FLJ76029 complete cds, highly similar to Homo sapiens plasminogen activator, urokinase receptor (PLAUR), transcript variant 1, mRNA.
M83246 - Human monocyte activation antigen (Mo3) mRNA, complete cds.
BC002788 - Homo sapiens plasminogen activator, urokinase receptor, mRNA (cDNA clone MGC:3905 IMAGE:3617894), complete cds.
DQ893017 - Synthetic construct clone IMAGE:100005647; FLH191710.01X; RZPDo839G0277D plasminogen activator, urokinase receptor (PLAUR) gene, encodes complete protein.
KJ891821 - Synthetic construct Homo sapiens clone ccsbBroadEn_01215 PLAUR gene, encodes complete protein.
DQ896262 - Synthetic construct Homo sapiens clone IMAGE:100010722; FLH191706.01L; RZPDo839G0267D plasminogen activator, urokinase receptor (PLAUR) gene, encodes complete protein.
AB464026 - Synthetic construct DNA, clone: pF1KB6412, Homo sapiens PLAUR gene for plasminogen activator, urokinase receptor, without stop codon, in Flexi system.
AF257789 - Homo sapiens urokinase-type plasminogen activator receptor mRNA, partial cds.
AY029180 - Homo sapiens soluble urokinase plasminogen activator receptor precursor (SUPAR) mRNA, complete cds.
U09347 - Human variant urokinase plasminogen activator receptor (uPAR2) mRNA, partial cds.
JD043434 - Sequence 24458 from Patent EP1572962.
JD185996 - Sequence 167020 from Patent EP1572962.
JD548791 - Sequence 529815 from Patent EP1572962.
JD096784 - Sequence 77808 from Patent EP1572962.
JD459971 - Sequence 440995 from Patent EP1572962.
JD282138 - Sequence 263162 from Patent EP1572962.
JD327086 - Sequence 308110 from Patent EP1572962.
JD504858 - Sequence 485882 from Patent EP1572962.
JD383579 - Sequence 364603 from Patent EP1572962.
JD168206 - Sequence 149230 from Patent EP1572962.
JD484090 - Sequence 465114 from Patent EP1572962.
JD209296 - Sequence 190320 from Patent EP1572962.
JD151401 - Sequence 132425 from Patent EP1572962.
JD476011 - Sequence 457035 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04610 - Complement and coagulation cascades

Reactome (by CSHL, EBI, and GO)

Protein Q03405 (Reactome details) participates in the following event(s):

R-HSA-158959 urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR
R-HSA-162729 uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid
R-HSA-162836 uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide
R-HSA-158942 urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
R-HSA-159001 urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
R-HSA-159005 urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-158982 plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
R-HSA-158925 plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
R-HSA-75205 Dissolution of Fibrin Clot
R-HSA-162791 Attachment of GPI anchor to uPAR
R-HSA-109582 Hemostasis
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-597592 Post-translational protein modification
R-HSA-168249 Innate Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A8K409, MO3, NM_002659, NP_002650, Q03405, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0, UPAR, UPAR_HUMAN
UCSC ID: uc002oxf.2
RefSeq Accession: NM_002659
Protein: Q03405 (aka UPAR_HUMAN)
CCDS: CCDS12628.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002659.3
exon count: 7CDS single in 3' UTR: no RNA size: 1570
ORF size: 1008CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2072.00frame shift in genome: no % Coverage: 98.92
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.