Human Gene PLAUR (uc002oxf.2) Description and Page Index
Description: Homo sapiens plasminogen activator, urokinase receptor (PLAUR), transcript variant 1, mRNA. RefSeq Summary (NM_002659): This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:44,152,723-44,174,498 Size: 21,776 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr19:44,153,042-44,174,272 Size: 21,231 Coding Exon Count: 7
ID:UPAR_HUMAN DESCRIPTION: RecName: Full=Urokinase plasminogen activator surface receptor; Short=U-PAR; Short=uPAR; AltName: Full=Monocyte activation antigen Mo3; AltName: CD_antigen=CD87; Flags: Precursor; FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. SUBUNIT: Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable). TISSUE SPECIFICITY: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. SIMILARITY: Contains 3 UPAR/Ly6 domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/plaur/";
Genetic Association Studies of Complex Diseases and Disorders
Scleroderma, Systemic|Systemic Scleroderma|Vascular Diseases Manetti M et al. 2011, A genetic variation located in the promoter of the uPAR (CD87) gene is associated with the vascular complications of systemic sclerosis., Arthritis and rheumatism 63(1) : 247-56 2011.
The UPAR rs344781 gene variant is associated with the SSc vascular phenotype.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q03405
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.