Human Gene GMIP (uc002nnd.3) Description and Page Index
  Description: Homo sapiens GEM interacting protein (GMIP), mRNA.
RefSeq Summary (NM_016573): This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Transcript (Including UTRs)
   Position: hg19 chr19:19,740,285-19,754,455 Size: 14,171 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr19:19,740,772-19,754,338 Size: 13,567 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:19,740,285-19,754,455)mRNA (may differ from genome)Protein (970 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=GEM-interacting protein; Short=GMIP;
FUNCTION: Stimulates, in vitro and in vivo, the GTPase activity of RhoA.
SUBUNIT: Interacts with GEM through its N-terminal.
SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger.
SIMILARITY: Contains 1 Rho-GAP domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GMIP
CDC HuGE Published Literature: GMIP
Positive Disease Associations: depressive disorder, major
Related Studies:
  1. depressive disorder, major
    Tadokoro, K. et al. 2005, The Gem interacting protein (GMIP) gene is associated with major depressive disorder., Neurogenetics. 2005 Sep;6(3):127-33. [PubMed 16086184]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 83.50 RPKM in Whole Blood
Total median expression: 329.13 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.20117-0.403 Picture PostScript Text
3' UTR -184.90487-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002219 - Prot_Kinase_C-like_PE/DAG-bd
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom

Pfam Domains:
PF00620 - RhoGAP domain

SCOP Domains:
48350 - GTPase activation domain, GAP
57889 - Cysteine-rich domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9P107
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0007165 signal transduction
GO:0034260 negative regulation of GTPase activity
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction

Cellular Component:
GO:0005622 intracellular
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

-  Descriptions from all associated GenBank mRNAs
  LF208126 - JP 2014500723-A/15629: Polycomb-Associated Non-Coding RNAs.
AF086104 - Homo sapiens full length insert cDNA clone YZ92H03.
AF132541 - Homo sapiens Gem-interacting protein (GMIP) mRNA, complete cds.
JD230646 - Sequence 211670 from Patent EP1572962.
JD205907 - Sequence 186931 from Patent EP1572962.
JD487058 - Sequence 468082 from Patent EP1572962.
JD165578 - Sequence 146602 from Patent EP1572962.
JD078524 - Sequence 59548 from Patent EP1572962.
JD248335 - Sequence 229359 from Patent EP1572962.
LF372620 - JP 2014500723-A/180123: Polycomb-Associated Non-Coding RNAs.
JD073310 - Sequence 54334 from Patent EP1572962.
AK297220 - Homo sapiens cDNA FLJ56574 complete cds, highly similar to GEM-interacting protein.
BC126436 - Homo sapiens GEM interacting protein, mRNA (cDNA clone MGC:161714 IMAGE:8992152), complete cds.
BC144142 - Homo sapiens GEM interacting protein, mRNA (cDNA clone MGC:177679 IMAGE:9052662), complete cds.
JD069189 - Sequence 50213 from Patent EP1572962.
KJ893873 - Synthetic construct Homo sapiens clone ccsbBroadEn_03267 GMIP gene, encodes complete protein.
LF372619 - JP 2014500723-A/180122: Polycomb-Associated Non-Coding RNAs.
BC032057 - Homo sapiens GEM interacting protein, mRNA (cDNA clone IMAGE:5174902).
LF372616 - JP 2014500723-A/180119: Polycomb-Associated Non-Coding RNAs.
LF372615 - JP 2014500723-A/180118: Polycomb-Associated Non-Coding RNAs.
JD030336 - Sequence 11360 from Patent EP1572962.
JD021565 - Sequence 2589 from Patent EP1572962.
MA608197 - JP 2018138019-A/180123: Polycomb-Associated Non-Coding RNAs.
MA608196 - JP 2018138019-A/180122: Polycomb-Associated Non-Coding RNAs.
MA608193 - JP 2018138019-A/180119: Polycomb-Associated Non-Coding RNAs.
MA608192 - JP 2018138019-A/180118: Polycomb-Associated Non-Coding RNAs.
MA443703 - JP 2018138019-A/15629: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P107 (Reactome details) participates in the following event(s):

R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-194840 Rho GTPase cycle
R-HSA-194315 Signaling by Rho GTPases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVN9, GMIP_HUMAN, NM_016573, NP_057657, Q9P107
UCSC ID: uc002nnd.3
RefSeq Accession: NM_016573
Protein: Q9P107 (aka GMIP_HUMAN)
CCDS: CCDS12408.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_016573.2
exon count: 21CDS single in 3' UTR: no RNA size: 3532
ORF size: 2913CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6026.00frame shift in genome: no % Coverage: 99.58
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.