Human Gene GMIP (uc002nnd.3) Description and Page Index
Description: Homo sapiens GEM interacting protein (GMIP), mRNA. RefSeq Summary (NM_016573): This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Transcript (Including UTRs) Position: hg19 chr19:19,740,285-19,754,455 Size: 14,171 Total Exon Count: 21 Strand: - Coding Region Position: hg19 chr19:19,740,772-19,754,338 Size: 13,567 Coding Exon Count: 21
ID:GMIP_HUMAN DESCRIPTION: RecName: Full=GEM-interacting protein; Short=GMIP; FUNCTION: Stimulates, in vitro and in vivo, the GTPase activity of RhoA. SUBUNIT: Interacts with GEM through its N-terminal. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 Rho-GAP domain.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P107
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0034260 negative regulation of GTPase activity GO:0035556 intracellular signal transduction GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction