ID:BIN2_HUMAN DESCRIPTION: RecName: Full=Bridging integrator 2; AltName: Full=Breast cancer-associated protein 1; SUBUNIT: Interacts with BIN1. INTERACTION: O00499:BIN1; NbExp=2; IntAct=EBI-2042570, EBI-719094; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. INDUCTION: Up-regulated during monocytic differentiation. SIMILARITY: Contains 1 BAR domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): BIN2 CDC HuGE Published Literature: BIN2 Positive Disease Associations: Longevity Related Studies:
Longevity Stefan Walter et al. Neurobiology of aging 2011, A genome-wide association study of aging., Neurobiology of aging.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBW5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.