Human Gene C3AR1 (uc001qtv.1) Description and Page Index
Description: Homo sapiens complement component 3a receptor 1 (C3AR1), mRNA. RefSeq Summary (NM_004054): C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]. Transcript (Including UTRs) Position: hg19 chr12:8,210,919-8,218,955 Size: 8,037 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr12:8,211,333-8,212,781 Size: 1,449 Coding Exon Count: 1
ID:C3AR_HUMAN DESCRIPTION: RecName: Full=C3a anaphylatoxin chemotactic receptor; Short=C3AR; Short=C3a-R; FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. PTM: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/c3ar1/";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): C3AR1 CDC HuGE Published Literature: C3AR1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q16581
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.