Human Gene ZNHIT1 (uc003uye.3) Description and Page Index
  Description: Homo sapiens zinc finger, HIT-type containing 1 (ZNHIT1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:100,860,985-100,867,471 Size: 6,487 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr7:100,861,477-100,867,239 Size: 5,763 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:100,860,985-100,867,471)mRNA (may differ from genome)Protein (154 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger HIT domain-containing protein 1; AltName: Full=Cyclin-G1-binding protein 1; AltName: Full=Zinc finger protein subfamily 4A member 1; AltName: Full=p18 Hamlet;
FUNCTION: Seems to play a role in p53-mediated apoptosis induction.
SUBUNIT: Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1.
INDUCTION: Induced by DNA damage.
PTM: Phosphorylated on Thr by MAPK11 or MAPK14.
PTM: Stres-induced ZNHIT1 is mainly regulated at the level of protein.
SIMILARITY: Belongs to the ZNHIT1 family.
SIMILARITY: Contains 1 HIT-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 112.94 RPKM in Liver
Total median expression: 2829.62 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -175.83492-0.357 Picture PostScript Text
3' UTR -83.83232-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007529 - Znf_HIT

Pfam Domains:
PF04438 - HIT zinc finger

ModBase Predicted Comparative 3D Structure on O43257
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding

Biological Process:
GO:0031063 regulation of histone deacetylation
GO:0043486 histone exchange

Cellular Component:
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm

-  Descriptions from all associated GenBank mRNAs
  LF206982 - JP 2014500723-A/14485: Polycomb-Associated Non-Coding RNAs.
BC017333 - Homo sapiens zinc finger, HIT type 1, mRNA (cDNA clone MGC:29531 IMAGE:4647446), complete cds.
JA482162 - Sequence 145 from Patent WO2011072091.
JB252015 - Sequence 82 from Patent EP2440214.
JE980454 - Sequence 145 from Patent EP2862929.
LF384054 - JP 2014500723-A/191557: Polycomb-Associated Non-Coding RNAs.
LP764914 - Sequence 82 from Patent EP3276004.
BC001877 - Homo sapiens cDNA clone IMAGE:3546408, containing frame-shift errors.
LF359906 - JP 2014500723-A/167409: Polycomb-Associated Non-Coding RNAs.
AF093571 - Homo sapiens cyclin G1 binding protein 1 mRNA, complete cds.
AK312136 - Homo sapiens cDNA, FLJ92418, highly similar to Homo sapiens zinc finger, HIT domain containing 1 (ZNHIT1), mRNA.
U61837 - Homo sapiens putative cyclin G1 interacting protein mRNA, complete cds.
AK125123 - Homo sapiens cDNA FLJ43133 fis, clone CTONG3006067.
CR456992 - Homo sapiens full open reading frame cDNA clone RZPDo834E045D for gene ZNHIT1, zinc finger, HIT domain containing 1; complete cds, incl. stopcodon.
AB590267 - Synthetic construct DNA, clone: pFN21AE1113, Homo sapiens ZNHIT1 gene for zinc finger, HIT type 1, without stop codon, in Flexi system.
DQ892275 - Synthetic construct clone IMAGE:100004905; FLH184783.01X; RZPDo839B10146D zinc finger, HIT type 1 (ZNHIT1) gene, encodes complete protein.
DQ895476 - Synthetic construct Homo sapiens clone IMAGE:100009936; FLH184779.01L; RZPDo839B10145D zinc finger, HIT type 1 (ZNHIT1) gene, encodes complete protein.
KJ893050 - Synthetic construct Homo sapiens clone ccsbBroadEn_02444 ZNHIT1 gene, encodes complete protein.
BC010454 - Homo sapiens zinc finger, HIT type 1, mRNA (cDNA clone IMAGE:4181647), with apparent retained intron.
AK092478 - Homo sapiens cDNA FLJ35159 fis, clone PLACE6011260.
LF359905 - JP 2014500723-A/167408: Polycomb-Associated Non-Coding RNAs.
JD216190 - Sequence 197214 from Patent EP1572962.
JD442429 - Sequence 423453 from Patent EP1572962.
LF359904 - JP 2014500723-A/167407: Polycomb-Associated Non-Coding RNAs.
JD316693 - Sequence 297717 from Patent EP1572962.
JD109068 - Sequence 90092 from Patent EP1572962.
JD198701 - Sequence 179725 from Patent EP1572962.
JD045386 - Sequence 26410 from Patent EP1572962.
JD494373 - Sequence 475397 from Patent EP1572962.
JD372395 - Sequence 353419 from Patent EP1572962.
JD202834 - Sequence 183858 from Patent EP1572962.
JD247369 - Sequence 228393 from Patent EP1572962.
JD366973 - Sequence 347997 from Patent EP1572962.
MA619631 - JP 2018138019-A/191557: Polycomb-Associated Non-Coding RNAs.
MA442559 - JP 2018138019-A/14485: Polycomb-Associated Non-Coding RNAs.
MA595483 - JP 2018138019-A/167409: Polycomb-Associated Non-Coding RNAs.
MA595482 - JP 2018138019-A/167408: Polycomb-Associated Non-Coding RNAs.
MA595481 - JP 2018138019-A/167407: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CGBP1, NM_006349, NP_006340, O43257, Q6IB12, ZNFN4A1, ZNHI1_HUMAN
UCSC ID: uc003uye.3
RefSeq Accession: NM_006349
Protein: O43257 (aka ZNHI1_HUMAN or ZNH1_HUMAN)
CCDS: CCDS5716.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_006349.2
exon count: 5CDS single in 3' UTR: no RNA size: 1208
ORF size: 465CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 924.00frame shift in genome: no % Coverage: 98.43
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.