Human Gene SNRPD2 (uc002pcw.3) Description and Page Index
Description: Homo sapiens small nuclear ribonucleoprotein D2 polypeptide 16.5kDa (SNRPD2), transcript variant 1, mRNA. RefSeq Summary (NM_004597): The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. Transcript (Including UTRs) Position: hg19 chr19:46,190,712-46,195,443 Size: 4,732 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr19:46,190,811-46,195,146 Size: 4,336 Coding Exon Count: 3
ID:SMD2_HUMAN DESCRIPTION: RecName: Full=Small nuclear ribonucleoprotein Sm D2; Short=Sm-D2; AltName: Full=snRNP core protein D2; FUNCTION: Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). SUBUNIT: Identified in the spliceosome C complex. composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity. SIMILARITY: Belongs to the snRNP core protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62316
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.