Human Gene C19orf53 (uc002mxg.3) Description and Page Index
  Description: Homo sapiens chromosome 19 open reading frame 53 (C19orf53), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:13,885,257-13,889,586 Size: 4,330 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:13,885,292-13,889,012 Size: 3,721 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:13,885,257-13,889,586)mRNA (may differ from genome)Protein (99 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: L10K_HUMAN
DESCRIPTION: RecName: Full=Leydig cell tumor 10 kDa protein homolog;
FUNCTION: May have a potential role in hypercalcemia of malignancy (By similarity).
SIMILARITY: Belongs to the UPF0390 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C19orf53
CDC HuGE Published Literature: C19orf53

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 98.20 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 3219.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.5035-0.214 Picture PostScript Text
3' UTR -202.60574-0.353 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019034 - UPF0390

Pfam Domains:
PF09495 - Protein of unknown function (DUF2462)

ModBase Predicted Comparative 3D Structure on Q9UNZ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  BC015465 - Homo sapiens chromosome 19 open reading frame 53, mRNA (cDNA clone MGC:8754 IMAGE:3914049), complete cds.
AF086483 - Homo sapiens full length insert cDNA clone ZD92G09.
AF078852 - Homo sapiens HSPC023 mRNA, complete cds.
DQ891569 - Synthetic construct clone IMAGE:100004199; FLH178219.01X; RZPDo839A08128D HSPC023 protein (HSPC023) gene, encodes complete protein.
DQ894761 - Synthetic construct Homo sapiens clone IMAGE:100009221; FLH178215.01L; RZPDo839A08127D HSPC023 protein (HSPC023) gene, encodes complete protein.
KJ893656 - Synthetic construct Homo sapiens clone ccsbBroadEn_03050 C19orf53 gene, encodes complete protein.
AK311855 - Homo sapiens cDNA, FLJ92121, Homo sapiens HSPC023 protein (HSPC023), mRNA.
JD150317 - Sequence 131341 from Patent EP1572962.
JD249092 - Sequence 230116 from Patent EP1572962.
JD468551 - Sequence 449575 from Patent EP1572962.
JD144085 - Sequence 125109 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4J9, HSPC023, L10K_HUMAN, NM_014047, NP_054766, Q9UNZ5
UCSC ID: uc002mxg.3
RefSeq Accession: NM_014047
Protein: Q9UNZ5 (aka L10K_HUMAN)
CCDS: CCDS12298.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014047.2
exon count: 3CDS single in 3' UTR: no RNA size: 934
ORF size: 300CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 500.00frame shift in genome: no % Coverage: 97.32
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.