Human Gene DDX24 (uc001ycj.3) Description and Page Index
  Description: Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (DDX24), mRNA.
RefSeq Summary (NM_020414): DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.211782.1, SRR1803614.143602.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000621632.5/ ENSP00000481495.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr14:94,517,268-94,547,558 Size: 30,291 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr14:94,517,537-94,546,088 Size: 28,552 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:94,517,268-94,547,558)mRNA (may differ from genome)Protein (859 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ATP-dependent RNA helicase DDX24; EC=; AltName: Full=DEAD box protein 24;
FUNCTION: ATP-dependent RNA helicase (Potential).
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
TISSUE SPECIFICITY: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 112.18 RPKM in Testis
Total median expression: 2953.33 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.2099-0.376 Picture PostScript Text
3' UTR -62.75269-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR000629 - RNA-helicase_DEAD-box_CS
IPR014014 - RNA_helicase_DEAD_Q_motif

Pfam Domains:
PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9GZR7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Biological Process:
GO:0010501 RNA secondary structure unwinding
GO:0016070 RNA metabolic process

Cellular Component:
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane

-  Descriptions from all associated GenBank mRNAs
  AB209382 - Homo sapiens mRNA for DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 variant protein.
BX537533 - Homo sapiens mRNA; cDNA DKFZp686E1786 (from clone DKFZp686E1786).
BC000778 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 24, mRNA (cDNA clone IMAGE:3507749), partial cds.
AF145022 - Homo sapiens ATP-dependent RNA helicase mRNA, complete cds.
BC096826 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 24, mRNA (cDNA clone MGC:111390 IMAGE:30925011), complete cds.
AL136886 - Homo sapiens mRNA; cDNA DKFZp434A0772 (from clone DKFZp434A0772).
BC008847 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 24, mRNA (cDNA clone MGC:14392 IMAGE:4301025), complete cds.
BC009406 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 24, mRNA (cDNA clone MGC:14942 IMAGE:4303448), complete cds.
AK025162 - Homo sapiens cDNA: FLJ21509 fis, clone COL05745.
AF214731 - Homo sapiens ATP-dependent RNA helicase (DDX24) mRNA, complete cds.
AK304504 - Homo sapiens cDNA FLJ52397 complete cds, highly similar to ATP-dependent RNA helicase DDX24 (EC 3.6.1.-).
AK297232 - Homo sapiens cDNA FLJ50574 complete cds, highly similar to ATP-dependent RNA helicase DDX24 (EC 3.6.1.-).
AF134475 - Homo sapiens ATP-dependent RNA helicase mRNA, complete cds.
JD187741 - Sequence 168765 from Patent EP1572962.
AK294613 - Homo sapiens cDNA FLJ50498 complete cds, highly similar to ATP-dependent RNA helicase DDX24 (EC 3.6.1.-).
AK296726 - Homo sapiens cDNA FLJ54363 complete cds, highly similar to ATP-dependent RNA helicase DDX24 (EC 3.6.1.-).
JD512575 - Sequence 493599 from Patent EP1572962.
JD394347 - Sequence 375371 from Patent EP1572962.
JD415368 - Sequence 396392 from Patent EP1572962.
DQ893523 - Synthetic construct clone IMAGE:100006153; FLH195019.01X; RZPDo839H0780D DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (DDX24) gene, encodes complete protein.
DQ896510 - Synthetic construct Homo sapiens clone IMAGE:100010970; FLH195015.01L; RZPDo839H0770D DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (DDX24) gene, encodes complete protein.
AB463005 - Synthetic construct DNA, clone: pF1KB8641, Homo sapiens DDX24 gene for DEAD (Asp-Glu-Ala-Asp) box polypeptide 24, without stop codon, in Flexi system.
AM393538 - Synthetic construct Homo sapiens clone IMAGE:100001750 for hypothetical protein (DDX24 gene).
DL491698 - Novel nucleic acids.
DL490280 - Novel nucleic acids.
AF161446 - Homo sapiens HSPC328 mRNA, partial cds.
DQ597771 - Homo sapiens piRNA piR-35837, complete sequence.
JD059907 - Sequence 40931 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DDX24_HUMAN, NM_020414, NP_065147, Q9GZR7
UCSC ID: uc001ycj.3
RefSeq Accession: NM_020414
Protein: Q9GZR7 (aka DDX24_HUMAN or DD24_HUMAN)
CCDS: CCDS9918.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_020414.3
exon count: 9CDS single in 3' UTR: no RNA size: 2967
ORF size: 2580CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5336.00frame shift in genome: no % Coverage: 99.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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