Human Gene PTGES3 (uc001slu.4) Description and Page Index
Description: Homo sapiens prostaglandin E synthase 3 (cytosolic) (PTGES3), mRNA. RefSeq Summary (NM_006601): This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]. Transcript (Including UTRs) Position: hg19 chr12:57,057,125-57,082,078 Size: 24,954 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr12:57,058,263-57,081,783 Size: 23,521 Coding Exon Count: 8
ID:TEBP_HUMAN DESCRIPTION: RecName: Full=Prostaglandin E synthase 3; EC=220.127.116.11; AltName: Full=Cytosolic prostaglandin E2 synthase; Short=cPGES; AltName: Full=Hsp90 co-chaperone; AltName: Full=Progesterone receptor complex p23; AltName: Full=Telomerase-binding protein p23; FUNCTION: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. CATALYTIC ACTIVITY: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=14 uM for PGH2; Vmax=190 nmol/min/mg enzyme toward PGH2; PATHWAY: Lipid metabolism; prostaglandin biosynthesis. SUBUNIT: Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. INTERACTION: P07900:HSP90AA1; NbExp=5; IntAct=EBI-1049387, EBI-296047; SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the p23/wos2 family. SIMILARITY: Contains 1 CS domain.
Genetic Association Studies of Complex Diseases and Disorders
Macular Degeneration Wei Chen et al. Proceedings of the National Academy of Sciences of the United States of America 2010, Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration., Proceedings of the National Academy of Sciences of the United States of America.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15185
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.