Human Gene STRAP (uc001rdc.4) Description and Page Index
  Description: Homo sapiens serine/threonine kinase receptor associated protein (STRAP), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:16,035,288-16,056,410 Size: 21,123 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr12:16,035,642-16,055,912 Size: 20,271 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:16,035,288-16,056,410)mRNA (may differ from genome)Protein (350 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Serine-threonine kinase receptor-associated protein; AltName: Full=MAP activator with WD repeats; AltName: Full=UNR-interacting protein; AltName: Full=WD-40 repeat protein PT-WD;
FUNCTION: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
SUBUNIT: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1.
INTERACTION: P15531:NME1; NbExp=9; IntAct=EBI-727414, EBI-741141;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
SIMILARITY: Belongs to the WD repeat STRAP family.
SIMILARITY: Contains 7 WD repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 75.21 RPKM in Cells - Transformed fibroblasts
Total median expression: 2623.77 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -114.70354-0.324 Picture PostScript Text
3' UTR -116.70498-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q9Y3F4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 Protein SequenceProtein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005102 receptor binding
GO:0005515 protein binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000387 spliceosomal snRNP assembly
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010633 negative regulation of epithelial cell migration
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032797 SMN complex
GO:0034719 SMN-Sm protein complex

-  Descriptions from all associated GenBank mRNAs
  AK074607 - Homo sapiens cDNA FLJ90126 fis, clone HEMBA1007332, weakly similar to Homo sapiens pt-wd mRNA for WD-40 repeat protein.
AK315891 - Homo sapiens cDNA, FLJ79540 complete cds, highly similar to Serine-threonine kinase receptor-associatedprotein.
AK297942 - Homo sapiens cDNA FLJ51909 complete cds, highly similar to Serine-threonine kinase receptor-associatedprotein.
BC062306 - Homo sapiens serine/threonine kinase receptor associated protein, mRNA (cDNA clone MGC:71292 IMAGE:3349549), complete cds.
JD023465 - Sequence 4489 from Patent EP1572962.
AF161496 - Homo sapiens HSPC147 mRNA, complete cds.
AB024327 - Homo sapiens pt-wd mRNA for WD-40 repeat protein, complete cds.
AL136691 - Homo sapiens mRNA; cDNA DKFZp564N1778 (from clone DKFZp564N1778).
AK312295 - Homo sapiens cDNA, FLJ92599, highly similar to Homo sapiens serine/threonine kinase receptor associated protein (STRAP), mRNA.
JD171648 - Sequence 152672 from Patent EP1572962.
JD192151 - Sequence 173175 from Patent EP1572962.
JD034651 - Sequence 15675 from Patent EP1572962.
JD417109 - Sequence 398133 from Patent EP1572962.
JD385961 - Sequence 366985 from Patent EP1572962.
JD130516 - Sequence 111540 from Patent EP1572962.
JD416605 - Sequence 397629 from Patent EP1572962.
JD227509 - Sequence 208533 from Patent EP1572962.
AJ010025 - Homo sapiens mRNA for unr-interacting protein.
BC000162 - Homo sapiens serine/threonine kinase receptor associated protein, mRNA (cDNA clone MGC:5236 IMAGE:2900954), complete cds.
JD347428 - Sequence 328452 from Patent EP1572962.
JD217140 - Sequence 198164 from Patent EP1572962.
U56430 - Human HeLa mRNA isolated as a false positive in a two-hybrid-screen.
AY049776 - Homo sapiens unr-interacting protein (UNRIP) mRNA, complete cds.
DQ890951 - Synthetic construct clone IMAGE:100003581; FLH167897.01X; RZPDo839G1290D serine/threonine kinase receptor associated protein (STRAP) gene, encodes complete protein.
DQ894113 - Synthetic construct Homo sapiens clone IMAGE:100008573; FLH167893.01L; RZPDo839G1289D serine/threonine kinase receptor associated protein (STRAP) gene, encodes complete protein.
AB385074 - Synthetic construct DNA, clone: pF1KB5266, Homo sapiens STRAP gene for serine-threonine kinase receptor-associated protein, complete cds, without stop codon, in Flexi system.
CU674068 - Synthetic construct Homo sapiens gateway clone IMAGE:100017068 5' read STRAP mRNA.
KJ893247 - Synthetic construct Homo sapiens clone ccsbBroadEn_02641 STRAP gene, encodes complete protein.
BT020044 - Homo sapiens unr-interacting protein mRNA, complete cds.
BT020045 - Homo sapiens unr-interacting protein mRNA, complete cds.
JD499178 - Sequence 480202 from Patent EP1572962.
JD284946 - Sequence 265970 from Patent EP1572962.
JD566942 - Sequence 547966 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y3F4 (Reactome details) participates in the following event(s):

R-HSA-2127562 STRAP binds phosphorylated TGF-beta receptor complex
R-HSA-2128994 STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5S5, MAWD, NM_007178, NP_009109, Q5TZT4, Q9NTK0, Q9UQC8, Q9Y3F4, STRAP_HUMAN, UNRIP
UCSC ID: uc001rdc.4
RefSeq Accession: NM_007178
Protein: Q9Y3F4 (aka STRAP_HUMAN or STRA_HUMAN)
CCDS: CCDS8676.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_007178.3
exon count: 10CDS single in 3' UTR: no RNA size: 1924
ORF size: 1053CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2145.50frame shift in genome: no % Coverage: 99.01
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.