Description: Homo sapiens sialidase 2 (cytosolic sialidase) (NEU2), mRNA. RefSeq Summary (NM_005383): This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:233,897,382-233,899,767 Size: 2,386 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr2:233,897,382-233,899,767 Size: 2,386 Coding Exon Count: 2
ModBase Predicted Comparative 3D Structure on Q9Y3R4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006629 lipid metabolic process GO:0006687 glycosphingolipid metabolic process GO:0006689 ganglioside catabolic process GO:0008152 metabolic process GO:0009313 oligosaccharide catabolic process GO:0016042 lipid catabolic process GO:0051692 cellular oligosaccharide catabolic process
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00511 - Other glycan degradation hsa00600 - Sphingolipid metabolism
Reactome (by CSHL, EBI, and GO)
Protein Q9Y3R4 (Reactome details) participates in the following event(s):
R-HSA-1605723 Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) R-HSA-4085029 NEU2 hydrolyzes Neu5Ac from glycoconjugates R-HSA-1660662 Glycosphingolipid metabolism R-HSA-4085001 Sialic acid metabolism R-HSA-428157 Sphingolipid metabolism R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-556833 Metabolism of lipids R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-1430728 Metabolism R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
