Description: Homo sapiens tryptophan 2,3-dioxygenase (TDO2), mRNA. RefSeq Summary (NM_005651): This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]. Transcript (Including UTRs) Position: hg19 chr4:156,824,845-156,841,558 Size: 16,714 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr4:156,824,911-156,841,142 Size: 16,232 Coding Exon Count: 12
schizophrenia | bipolar disorder Christine L Miller , et al. Schizophrenia research 2009 113(2-3):259-67, Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder., Schizophrenia research 2009 113(2-3):259-67.
[PubMed 19502010]
TDO2[CC]+MCHR2[GC]+MC5R[G, any] conferred an OR maximal for schizophrenia alone (4.84, p=0.005), carried by 8% of schizophrenia cases. For the broad diagnosis of schizophrenia plus bipolar disorder, the same genotype conferred an OR of 3.93, p= 0.014, carried by 7% of the cases. This genotype was not present in the African Americans of the study.
speech perception in dyslexia Roeske ,et al. 2009, First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children, Molecular psychiatry 2009 .
[PubMed 19786962]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48775
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006568 tryptophan metabolic process GO:0006569 tryptophan catabolic process GO:0019441 tryptophan catabolic process to kynurenine GO:0019442 tryptophan catabolic process to acetyl-CoA GO:0051289 protein homotetramerization GO:0055114 oxidation-reduction process
US Server
