Description: Homo sapiens inhibin, beta E (INHBE), mRNA. RefSeq Summary (NM_031479): This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]. Transcript (Including UTRs) Position: hg19 chr12:57,849,096-57,851,791 Size: 2,696 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr12:57,849,320-57,850,631 Size: 1,312 Coding Exon Count: 2
ID:INHBE_HUMAN DESCRIPTION: RecName: Full=Inhibin beta E chain; AltName: Full=Activin beta-E chain; Flags: Precursor; FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. SUBUNIT: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity). SUBCELLULAR LOCATION: Secreted (By similarity). SIMILARITY: Belongs to the TGF-beta family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P58166
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0010469 regulation of receptor activity GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0042981 regulation of apoptotic process GO:0043408 regulation of MAPK cascade GO:0048468 cell development GO:0060395 SMAD protein signal transduction
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
AK308647 - Homo sapiens cDNA, FLJ98688. AK075285 - Homo sapiens cDNA FLJ90804 fis, clone Y79AA1000426, highly similar to Inhibin beta E chain precursor. BC005161 - Homo sapiens inhibin, beta E, mRNA (cDNA clone MGC:4638 IMAGE:3529092), complete cds. AF412024 - Homo sapiens activin beta E subunit mRNA, complete cds. JD279309 - Sequence 260333 from Patent EP1572962. JD492345 - Sequence 473369 from Patent EP1572962. JD148582 - Sequence 129606 from Patent EP1572962. JD343789 - Sequence 324813 from Patent EP1572962. JF432681 - Synthetic construct Homo sapiens clone IMAGE:100073919 inhibin, beta E (INHBE) gene, encodes complete protein. KJ894898 - Synthetic construct Homo sapiens clone ccsbBroadEn_04292 INHBE gene, encodes complete protein. EU831419 - Synthetic construct Homo sapiens clone HAIB:100066448; DKFZo008B0617 inhibin, beta E protein (INHBE) gene, encodes complete protein. EU831512 - Synthetic construct Homo sapiens clone HAIB:100066541; DKFZo004B0618 inhibin, beta E protein (INHBE) gene, encodes complete protein. CQ873708 - Sequence 127 from Patent WO2004076622. DD413545 - Regulation of Mammalian Cells. JD195107 - Sequence 176131 from Patent EP1572962. JD196896 - Sequence 177920 from Patent EP1572962. JD475544 - Sequence 456568 from Patent EP1572962. JD049336 - Sequence 30360 from Patent EP1572962. JD548301 - Sequence 529325 from Patent EP1572962. JD045695 - Sequence 26719 from Patent EP1572962. JD343010 - Sequence 324034 from Patent EP1572962. JD323862 - Sequence 304886 from Patent EP1572962. JD521220 - Sequence 502244 from Patent EP1572962. JD309638 - Sequence 290662 from Patent EP1572962. JD309748 - Sequence 290772 from Patent EP1572962. JD068772 - Sequence 49796 from Patent EP1572962. JD276130 - Sequence 257154 from Patent EP1572962. JD428997 - Sequence 410021 from Patent EP1572962. JD445465 - Sequence 426489 from Patent EP1572962. JD058653 - Sequence 39677 from Patent EP1572962. JD299978 - Sequence 281002 from Patent EP1572962. JD541221 - Sequence 522245 from Patent EP1572962. JD262078 - Sequence 243102 from Patent EP1572962. JD165231 - Sequence 146255 from Patent EP1572962. JD542919 - Sequence 523943 from Patent EP1572962. JD213076 - Sequence 194100 from Patent EP1572962. JD463108 - Sequence 444132 from Patent EP1572962. JD413748 - Sequence 394772 from Patent EP1572962. JD533846 - Sequence 514870 from Patent EP1572962. JD185143 - Sequence 166167 from Patent EP1572962. JD322001 - Sequence 303025 from Patent EP1572962. JD322002 - Sequence 303026 from Patent EP1572962. JD068502 - Sequence 49526 from Patent EP1572962. JD552282 - Sequence 533306 from Patent EP1572962. JD329656 - Sequence 310680 from Patent EP1572962. JD488021 - Sequence 469045 from Patent EP1572962. JD261721 - Sequence 242745 from Patent EP1572962. JD264763 - Sequence 245787 from Patent EP1572962. JD476928 - Sequence 457952 from Patent EP1572962. JD311507 - Sequence 292531 from Patent EP1572962. JD311508 - Sequence 292532 from Patent EP1572962. JD112794 - Sequence 93818 from Patent EP1572962. JD268235 - Sequence 249259 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04350 - TGF-beta signaling pathway