Human Gene NRROS (uc003fwv.3)
  Description: Homo sapiens leucine rich repeat containing 33 (NRROS), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:196,366,656-196,388,874 Size: 22,219 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr3:196,381,411-196,388,593 Size: 7,183 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:196,366,656-196,388,874)mRNA (may differ from genome)Protein (692 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMGIneXtProtOMIM
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LRC33_HUMAN
DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 33; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Contains 21 LRR (leucine-rich) repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.76 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 146.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.20104-0.521 Picture PostScript Text
3' UTR -50.10281-0.178 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp

Pfam Domains:
PF00560 - Leucine Rich Repeat
PF13306 - Leucine rich repeats (6 copies)
PF13516 - Leucine Rich repeat
PF13855 - Leucine rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q86YC3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0002376 immune system process
GO:0006801 superoxide metabolic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0045087 innate immune response

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LP896286 - Sequence 1150 from Patent EP3253886.
BC034704 - Homo sapiens cDNA clone IMAGE:4510430, containing frame-shift errors.
BC044233 - Homo sapiens leucine rich repeat containing 33, mRNA (cDNA clone MGC:50789 IMAGE:5725567), complete cds.
AY358322 - Homo sapiens clone DNA130809 ELLP3030 (UNQ3030) mRNA, complete cds.
KJ896154 - Synthetic construct Homo sapiens clone ccsbBroadEn_05548 LRRC33 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: LRC33_HUMAN, LRRC33, NM_198565, NP_940967, Q86YC3, UNQ3030/PRO9833
UCSC ID: uc003fwv.3
RefSeq Accession: NM_198565
Protein: Q86YC3 (aka LRC33_HUMAN)
CCDS: CCDS3319.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198565.1
exon count: 3CDS single in 3' UTR: no RNA size: 2488
ORF size: 2079CDS single in intron: no Alignment % ID: 99.88
txCdsPredict score: 4310.00frame shift in genome: no % Coverage: 99.04
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.