Human Gene OXNAD1 (uc003caw.3)
  Description: Homo sapiens oxidoreductase NAD-binding domain containing 1 (OXNAD1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:16,306,667-16,347,594 Size: 40,928 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr3:16,312,460-16,345,069 Size: 32,610 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:16,306,667-16,347,594)mRNA (may differ from genome)Protein (312 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OXND1_HUMAN
DESCRIPTION: RecName: Full=Oxidoreductase NAD-binding domain-containing protein 1; EC=1.-.-.-; Flags: Precursor;
SIMILARITY: Contains 1 FAD-binding FR-type domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): OXNAD1
CDC HuGE Published Literature: OXNAD1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.93 RPKM in Small Intestine - Terminal Ileum
Total median expression: 81.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -184.20504-0.365 Picture PostScript Text
3' UTR -827.262525-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017927 - Fd_Rdtase_FAD-bd
IPR001433 - OxRdtase_FAD/NAD-bd
IPR001221 - Phe_hydroxylase
IPR017938 - Riboflavin_synthase-like_b-brl

Pfam Domains:
PF00175 - Oxidoreductase NAD-binding domain
PF08030 - Ferric reductase NAD binding domain

SCOP Domains:
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain

ModBase Predicted Comparative 3D Structure on Q96HP4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0016491 oxidoreductase activity

Biological Process:
GO:0008150 biological_process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005575 cellular_component
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  DQ364598 - Homo sapiens oxidoreductase NAD-binding domain-containing 1 variant mRNA, complete cds.
AK307258 - Homo sapiens cDNA, FLJ97206.
BC008322 - Homo sapiens oxidoreductase NAD-binding domain containing 1, mRNA (cDNA clone MGC:15763 IMAGE:3358042), complete cds.
JD337343 - Sequence 318367 from Patent EP1572962.
JD199009 - Sequence 180033 from Patent EP1572962.
JD220605 - Sequence 201629 from Patent EP1572962.
JD162777 - Sequence 143801 from Patent EP1572962.
JD359224 - Sequence 340248 from Patent EP1572962.
JD493540 - Sequence 474564 from Patent EP1572962.
JD250763 - Sequence 231787 from Patent EP1572962.
AK298829 - Homo sapiens cDNA FLJ54836 complete cds.
JD257776 - Sequence 238800 from Patent EP1572962.
AB529111 - Synthetic construct DNA, clone: pF1KB4671, Homo sapiens OXNAD1 gene for oxidoreductase NAD-binding domain containing protein 1, without stop codon, in Flexi system.
HQ448162 - Synthetic construct Homo sapiens clone IMAGE:100071549; CCSB005302_01 oxidoreductase NAD-binding domain containing 1 (OXNAD1) gene, encodes complete protein.
KJ895175 - Synthetic construct Homo sapiens clone ccsbBroadEn_04569 OXNAD1 gene, encodes complete protein.
AB209556 - Homo sapiens mRNA for hypothetical protein BC008322 variant protein.
AL832787 - Homo sapiens mRNA; cDNA DKFZp667E0423 (from clone DKFZp667E0423).
JD053351 - Sequence 34375 from Patent EP1572962.
DQ588616 - Homo sapiens piRNA piR-55728, complete sequence.
BC007285 - Homo sapiens oxidoreductase NAD-binding domain containing 1, mRNA (cDNA clone IMAGE:3344267).
BC018770 - Homo sapiens oxidoreductase NAD-binding domain containing 1, mRNA (cDNA clone IMAGE:4649198), with apparent retained intron.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_138381, NP_612390, OXND1_HUMAN, Q2HYC7, Q59FA4, Q96HP4
UCSC ID: uc003caw.3
RefSeq Accession: NM_138381
Protein: Q96HP4 (aka OXND1_HUMAN)
CCDS: CCDS2630.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_138381.3
exon count: 9CDS single in 3' UTR: no RNA size: 3992
ORF size: 939CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1819.50frame shift in genome: no % Coverage: 99.40
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 2495# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.