Description: Homo sapiens coiled-coil domain containing 65 (CCDC65), mRNA. RefSeq Summary (NM_033124): This gene encodes a sperm tail protein that is highly expressed in adult testis, spermatocytes and spermatids. The protein plays a critical role in the assembly of the nexin-dynein regulatory complex. Mutations in this gene result in primary ciliary dyskinesia. [provided by RefSeq, Nov 2013]. Transcript (Including UTRs) Position: hg19 chr12:49,297,893-49,315,359 Size: 17,467 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr12:49,298,120-49,315,226 Size: 17,107 Coding Exon Count: 8
ID:CCD65_HUMAN DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 65; AltName: Full=Testis development protein NYD-SP28; TISSUE SPECIFICITY: Highly expressed in adult testis, in spermatocytes and spermatids. Also observed in spermatogonia. Not detected in Leydig cells, nor in fetal testis (at protein level). SEQUENCE CAUTION: Sequence=BAC05324.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IXS2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.