Description: Homo sapiens tryptase delta 1 (TPSD1), mRNA. RefSeq Summary (NM_012217): Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr16:1,306,273-1,308,494 Size: 2,222 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr16:1,306,282-1,308,377 Size: 2,096 Coding Exon Count: 5
ID:TRYD_HUMAN DESCRIPTION: RecName: Full=Tryptase delta; EC=3.4.21.59; AltName: Full=Delta-tryptase; AltName: Full=HmMCP-3-like tryptase III; AltName: Full=Mast cell mMCP-7-like; AltName: Full=Tryptase-3; Flags: Precursor; FUNCTION: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity). CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin. SUBUNIT: Homotetramer (By similarity). SUBCELLULAR LOCATION: Secreted (By similarity). Note=Released from the secretory granules upon mast cell activation (By similarity). TISSUE SPECIFICITY: Expressed in colon, lung, heart and synovial tissue. May be specific to mast cells. SIMILARITY: Belongs to the peptidase S1 family. Tryptase subfamily. SIMILARITY: Contains 1 peptidase S1 domain. CAUTION: Although PubMed:11174199 reported this as a pseudogene, PubMed:12391231 showed it is expressed and has proteolytic activity when expressed in bacterial cells. SEQUENCE CAUTION: Sequence=AAD17861.1; Type=Erroneous initiation; Sequence=AAK12909.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZJ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.