Human Gene GRB7 (uc021twu.1) Description and Page Index
  Description: Homo sapiens growth factor receptor-bound protein 7 (GRB7), transcript variant 4, mRNA.
RefSeq Summary (NM_001242442): The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Transcript (Including UTRs)
   Position: hg19 chr17:37,895,024-37,903,538 Size: 8,515 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr17:37,895,159-37,903,150 Size: 7,992 Coding Exon Count: 15 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:37,895,024-37,903,538)mRNA (may differ from genome)Protein (555 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
ReactomeStanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GRB7
CDC HuGE Published Literature: GRB7

-  MalaCards Disease Associations
  MalaCards Gene Search: GRB7
Diseases sorted by gene-association score: silver-russell syndrome (5), breast cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.96 RPKM in Esophagus - Mucosa
Total median expression: 219.66 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.50135-0.470 Picture PostScript Text
3' UTR -162.76388-0.419 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00017 - SH2 domain
PF00169 - PH domain
PF00788 - Ras association (RalGDS/AF-6) domain
PF08947 - BPS (Between PH and SH2)

SCOP Domains:
50729 - PH domain-like
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q14451-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  KJ891295 - Synthetic construct Homo sapiens clone ccsbBroadEn_00689 GRB7 gene, encodes complete protein.
AK314368 - Homo sapiens cDNA, FLJ95136, highly similar to Homo sapiens growth factor receptor-bound protein 7 (GRB7), mRNA.
AK222849 - Homo sapiens mRNA for growth factor receptor-bound protein 7 variant, clone: HEP10521.
AK222870 - Homo sapiens mRNA for growth factor receptor-bound protein 7 variant, clone: HEP15586.
AK027729 - Homo sapiens cDNA FLJ14823 fis, clone OVARC1000649, highly similar to Growth factor receptor-bound protein 7.
D43772 - Homo sapiens mRNA for GRB-7 SH2 domain protein, complete cds.
AK294620 - Homo sapiens cDNA FLJ57923 complete cds, highly similar to Growth factor receptor-bound protein 7.
BC006535 - Homo sapiens growth factor receptor-bound protein 7, mRNA (cDNA clone MGC:1444 IMAGE:2824302), complete cds.
AK125544 - Homo sapiens cDNA FLJ43556 fis, clone PROST2018511, highly similar to Growth factor receptor-bound protein 7.
AK290115 - Homo sapiens cDNA FLJ75489 complete cds, highly similar to Homo sapiens growth factor receptor-bound protein 7, transcript variant 2, mRNA.
JD218069 - Sequence 199093 from Patent EP1572962.
AB008789 - Homo sapiens mRNA for grb7 protein, complete cds.
AB008790 - Homo sapiens mRNA for Grb7V protein, complete cds.
AB528516 - Synthetic construct DNA, clone: pF1KB5920, Homo sapiens GRB7 gene for growth factor receptor-bound protein 7, without stop codon, in Flexi system.
DQ893861 - Synthetic construct Homo sapiens clone IMAGE:100008321; FLH165033.01L; RZPDo839F01157D growth factor receptor-bound protein 7 (GRB7) gene, encodes complete protein.
EU176171 - Synthetic construct Homo sapiens clone IMAGE:100006339; FLH165040.01X; RZPDo839H01250D growth factor receptor-bound protein 7 (GRB7) gene, encodes complete protein.
CU675443 - Synthetic construct Homo sapiens gateway clone IMAGE:100018359 5' read GRB7 mRNA.
KU178103 - Homo sapiens growth factor receptor-bound protein 7 isoform 1 (GRB7) mRNA, partial cds.
KU178104 - Homo sapiens growth factor receptor-bound protein 7 isoform 2 (GRB7) mRNA, complete cds, alternatively spliced.
BT006686 - Homo sapiens growth factor receptor-bound protein 7 mRNA, complete cds.
D87513 - Homo sapiens mRNA for Grb7 protein, partial cds.
JD479757 - Sequence 460781 from Patent EP1572962.
JD270905 - Sequence 251929 from Patent EP1572962.
JD483858 - Sequence 464882 from Patent EP1572962.
JD109862 - Sequence 90886 from Patent EP1572962.
JD293778 - Sequence 274802 from Patent EP1572962.
JD536750 - Sequence 517774 from Patent EP1572962.
JD124472 - Sequence 105496 from Patent EP1572962.
JD366820 - Sequence 347844 from Patent EP1572962.
JD191123 - Sequence 172147 from Patent EP1572962.
JD525752 - Sequence 506776 from Patent EP1572962.
JD108321 - Sequence 89345 from Patent EP1572962.
JD127716 - Sequence 108740 from Patent EP1572962.
JD153733 - Sequence 134757 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14451 (Reactome details) participates in the following event(s):

R-HSA-204773 Interaction of Tie2 and Grb7
R-HSA-382055 Grb7 binds to the active PDGF receptor
R-HSA-1306953 GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
R-HSA-1433501 Interaction of other adapter proteins with p-KIT
R-HSA-8853753 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10
R-HSA-210993 Tie2 Signaling
R-HSA-186763 Downstream signal transduction
R-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-8853659 RET signaling
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-186797 Signaling by PDGF
R-HSA-1227986 Signaling by ERBB2
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-422475 Axon guidance
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001242442, NP_005301, Q14451-3
UCSC ID: uc021twu.1
RefSeq Accession: NM_001242442
Protein: Q14451-3, splice isoform of Q14451 CCDS: CCDS11345.1, CCDS56028.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001242442.1
exon count: 15CDS single in 3' UTR: no RNA size: 2214
ORF size: 1668CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 3417.00frame shift in genome: no % Coverage: 98.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.