Human Gene SERINC2 (uc010ogh.2) Description and Page Index
  Description: Homo sapiens serine incorporator 2 (SERINC2), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:31,886,660-31,907,527 Size: 20,868 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr1:31,886,861-31,907,046 Size: 20,186 Coding Exon Count: 10 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:31,886,660-31,907,527)mRNA (may differ from genome)Protein (459 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
ReactomeStanford SOURCEUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 55.74 RPKM in Minor Salivary Gland
Total median expression: 528.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -51.00201-0.254 Picture PostScript Text
3' UTR -179.90481-0.374 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF03348 - Serine incorporator (Serinc)

ModBase Predicted Comparative 3D Structure on Q96SA4-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK127659 - Homo sapiens cDNA FLJ45757 fis, clone MESAN2014624, moderately similar to Mus musculus tumor differentially expressed 1, like (Tde1l).
AK298512 - Homo sapiens cDNA FLJ55933 complete cds, highly similar to Serine incorporator 2.
AY094595 - Homo sapiens tumor differentially expressed protein 2 (TDE2) mRNA, complete cds.
AK309409 - Homo sapiens cDNA, FLJ99450.
AK308031 - Homo sapiens cDNA, FLJ97979.
AY358560 - Homo sapiens clone DNA40625 GACL263 (UNQ263) mRNA, complete cds.
BC063006 - Homo sapiens serine incorporator 2, mRNA (cDNA clone IMAGE:5212698).
BC084580 - Homo sapiens serine incorporator 2, mRNA (cDNA clone MGC:90340 IMAGE:6500683), complete cds.
BC126283 - Homo sapiens serine incorporator 2, mRNA (cDNA clone MGC:161561 IMAGE:8991999), complete cds.
BC126285 - Homo sapiens serine incorporator 2, mRNA (cDNA clone MGC:161563 IMAGE:8992001), complete cds.
HQ258415 - Synthetic construct Homo sapiens clone IMAGE:100072844 serine incorporator 2 (SERINC2) (SERINC2) gene, encodes complete protein.
KJ904220 - Synthetic construct Homo sapiens clone ccsbBroadEn_13614 SERINC2 gene, encodes complete protein.
GQ129287 - Synthetic construct Homo sapiens clone HAIB:100068674; DKFZo004C1236 serine incorporator 2 protein (SERINC2) gene, partial cds.
GQ129288 - Synthetic construct Homo sapiens clone HAIB:100068577; DKFZo008C1235 serine incorporator 2 protein (SERINC2) gene, complete cds.
AF352325 - Homo sapiens FKSG84 mRNA, complete cds.
AK316357 - Homo sapiens cDNA, FLJ79256 complete cds, highly similar to Serine incorporator 2.
AK093784 - Homo sapiens cDNA FLJ36465 fis, clone THYMU2015321, moderately similar to Homo sapiens Diff33 protein homolog mRNA.
AX748305 - Sequence 1830 from Patent EP1308459.
AK296118 - Homo sapiens cDNA FLJ60277 complete cds, highly similar to Serine incorporator 2.
BC017085 - Homo sapiens serine incorporator 2, mRNA (cDNA clone IMAGE:3850147), partial cds.
JD152534 - Sequence 133558 from Patent EP1572962.
JD492879 - Sequence 473903 from Patent EP1572962.
BC007375 - Homo sapiens serine incorporator 2, mRNA (cDNA clone IMAGE:3639252), partial cds.
KJ904219 - Synthetic construct Homo sapiens clone ccsbBroadEn_13613 SERINC2 gene, encodes complete protein.
JD199314 - Sequence 180338 from Patent EP1572962.
JD115918 - Sequence 96942 from Patent EP1572962.
JD123741 - Sequence 104765 from Patent EP1572962.
JD097765 - Sequence 78789 from Patent EP1572962.
JD200448 - Sequence 181472 from Patent EP1572962.
JD352876 - Sequence 333900 from Patent EP1572962.
JD215989 - Sequence 197013 from Patent EP1572962.
JD111624 - Sequence 92648 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96SA4 (Reactome details) participates in the following event(s):

R-HSA-8932980 SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane
R-HSA-977347 Serine biosynthesis
R-HSA-70614 Amino acid synthesis and interconversion (transamination)
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: FKSG84, NM_018565, NP_001185968, Q96SA4-2, TDE2L, UNQ263/PRO300
UCSC ID: uc010ogh.2
RefSeq Accession: NM_018565
Protein: Q96SA4-2, splice isoform of Q96SA4 CCDS: CCDS55585.1, CCDS30662.1, CCDS55584.1, CCDS55583.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_018565.3
exon count: 10CDS single in 3' UTR: no RNA size: 2123
ORF size: 1380CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2633.00frame shift in genome: no % Coverage: 97.13
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.