Human Gene TMEM184A (uc003skv.4) Description and Page Index
  Description: Homo sapiens transmembrane protein 184A (TMEM184A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:1,581,871-1,596,066 Size: 14,196 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr7:1,586,588-1,595,120 Size: 8,533 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:1,581,871-1,596,066)mRNA (may differ from genome)Protein (413 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: T184A_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 184A;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM184 family.
SEQUENCE CAUTION: Sequence=BAC86522.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.23 RPKM in Esophagus - Mucosa
Total median expression: 181.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -167.90317-0.530 Picture PostScript Text
3' UTR -2322.274717-0.492 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005178 - Ost-alpha

Pfam Domains:
PF03619 - Organic solute transporter Ostalpha

ModBase Predicted Comparative 3D Structure on Q6ZMB5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0008201 heparin binding

Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK096817 - Homo sapiens cDNA FLJ39498 fis, clone PROST2016668.
AK126312 - Homo sapiens cDNA FLJ44335 fis, clone TRACH3004537, highly similar to Transmembrane protein 184A.
JD340547 - Sequence 321571 from Patent EP1572962.
JD118501 - Sequence 99525 from Patent EP1572962.
JD340546 - Sequence 321570 from Patent EP1572962.
JD118500 - Sequence 99524 from Patent EP1572962.
JD310152 - Sequence 291176 from Patent EP1572962.
JD442984 - Sequence 424008 from Patent EP1572962.
JD284676 - Sequence 265700 from Patent EP1572962.
JD558783 - Sequence 539807 from Patent EP1572962.
JD430957 - Sequence 411981 from Patent EP1572962.
JD558782 - Sequence 539806 from Patent EP1572962.
JD430956 - Sequence 411980 from Patent EP1572962.
JD471822 - Sequence 452846 from Patent EP1572962.
JD512824 - Sequence 493848 from Patent EP1572962.
JD197515 - Sequence 178539 from Patent EP1572962.
JD128510 - Sequence 109534 from Patent EP1572962.
JD256871 - Sequence 237895 from Patent EP1572962.
JD128460 - Sequence 109484 from Patent EP1572962.
JD547325 - Sequence 528349 from Patent EP1572962.
JD276413 - Sequence 257437 from Patent EP1572962.
JD221814 - Sequence 202838 from Patent EP1572962.
JD401164 - Sequence 382188 from Patent EP1572962.
JD216777 - Sequence 197801 from Patent EP1572962.
JD365827 - Sequence 346851 from Patent EP1572962.
JD137630 - Sequence 118654 from Patent EP1572962.
JD536784 - Sequence 517808 from Patent EP1572962.
JD192504 - Sequence 173528 from Patent EP1572962.
JD065812 - Sequence 46836 from Patent EP1572962.
JD187240 - Sequence 168264 from Patent EP1572962.
JD234304 - Sequence 215328 from Patent EP1572962.
JD330970 - Sequence 311994 from Patent EP1572962.
JD460613 - Sequence 441637 from Patent EP1572962.
JD190450 - Sequence 171474 from Patent EP1572962.
JD334720 - Sequence 315744 from Patent EP1572962.
JD048988 - Sequence 30012 from Patent EP1572962.
JD218060 - Sequence 199084 from Patent EP1572962.
JD391744 - Sequence 372768 from Patent EP1572962.
JD523926 - Sequence 504950 from Patent EP1572962.
JD158165 - Sequence 139189 from Patent EP1572962.
JD128059 - Sequence 109083 from Patent EP1572962.
JD413651 - Sequence 394675 from Patent EP1572962.
JD555883 - Sequence 536907 from Patent EP1572962.
JD200980 - Sequence 182004 from Patent EP1572962.
JD387618 - Sequence 368642 from Patent EP1572962.
JD371481 - Sequence 352505 from Patent EP1572962.
JD117602 - Sequence 98626 from Patent EP1572962.
JD445692 - Sequence 426716 from Patent EP1572962.
JD066095 - Sequence 47119 from Patent EP1572962.
JD520672 - Sequence 501696 from Patent EP1572962.
AK075043 - Homo sapiens cDNA FLJ90562 fis, clone OVARC1001163.
AK096790 - Homo sapiens cDNA FLJ39471 fis, clone PROST2012780.
BC026694 - Homo sapiens transmembrane protein 184A, mRNA (cDNA clone MGC:9712 IMAGE:3850351), complete cds.
AK172850 - Homo sapiens cDNA FLJ24011 fis, clone KAT10529.
JD396881 - Sequence 377905 from Patent EP1572962.
JD232657 - Sequence 213681 from Patent EP1572962.
JD540134 - Sequence 521158 from Patent EP1572962.
JD343307 - Sequence 324331 from Patent EP1572962.
JD393570 - Sequence 374594 from Patent EP1572962.
JD403330 - Sequence 384354 from Patent EP1572962.
JD071188 - Sequence 52212 from Patent EP1572962.
JD099103 - Sequence 80127 from Patent EP1572962.
JD163564 - Sequence 144588 from Patent EP1572962.
JD160516 - Sequence 141540 from Patent EP1572962.
JD155144 - Sequence 136168 from Patent EP1572962.
AK313249 - Homo sapiens cDNA, FLJ93755.
KJ904001 - Synthetic construct Homo sapiens clone ccsbBroadEn_13395 TMEM184A gene, encodes complete protein.
JD384659 - Sequence 365683 from Patent EP1572962.
JD216410 - Sequence 197434 from Patent EP1572962.
JD107272 - Sequence 88296 from Patent EP1572962.
JD163778 - Sequence 144802 from Patent EP1572962.
JD158137 - Sequence 139161 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001097620, NP_001091089, Q6ZMB5, Q8TBQ6, T184A_HUMAN
UCSC ID: uc003skv.4
RefSeq Accession: NM_001097620
Protein: Q6ZMB5 (aka T184A_HUMAN)
CCDS: CCDS43537.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001097620.1
exon count: 9CDS single in 3' UTR: no RNA size: 6293
ORF size: 1242CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2666.00frame shift in genome: no % Coverage: 99.73
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.