Human Gene RAB17 (uc002vwz.2) Description and Page Index
Description: Homo sapiens RAB17, member RAS oncogene family (RAB17), transcript variant 1, mRNA. RefSeq Summary (NM_022449): The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]. Transcript (Including UTRs) Position: hg19 chr2:238,482,965-238,499,769 Size: 16,805 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr2:238,483,662-238,494,797 Size: 11,136 Coding Exon Count: 5
ID:RAB17_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-17; FUNCTION: Might be involved in transcellular transport (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RAB17 CDC HuGE Published Literature: RAB17
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0T7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.