Human Gene RAB17 (uc002vwz.2) Description and Page Index
  Description: Homo sapiens RAB17, member RAS oncogene family (RAB17), transcript variant 1, mRNA.
RefSeq Summary (NM_022449): The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009].
Transcript (Including UTRs)
   Position: hg19 chr2:238,482,965-238,499,769 Size: 16,805 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr2:238,483,662-238,494,797 Size: 11,136 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:238,482,965-238,499,769)mRNA (may differ from genome)Protein (212 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: RAB17_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-17;
FUNCTION: Might be involved in transcellular transport (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RAB17
CDC HuGE Published Literature: RAB17

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.44 RPKM in Liver
Total median expression: 283.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -259.40663-0.391 Picture PostScript Text
3' UTR -295.44697-0.424 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9H0T7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding

Biological Process:
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO:0015031 protein transport
GO:0030100 regulation of endocytosis
GO:0032401 establishment of melanosome localization
GO:0032402 melanosome transport
GO:0032456 endocytic recycling
GO:0045056 transcytosis
GO:0046847 filopodium assembly
GO:0050773 regulation of dendrite development
GO:0051489 regulation of filopodium assembly
GO:0051963 regulation of synapse assembly
GO:0060271 cilium assembly

Cellular Component:
GO:0005622 intracellular
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030139 endocytic vesicle
GO:0030425 dendrite
GO:0042470 melanosome
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC007907 - Homo sapiens RAB17, member RAS oncogene family, mRNA (cDNA clone IMAGE:4299488), complete cds.
AK022600 - Homo sapiens cDNA FLJ12538 fis, clone NT2RM4000356, moderately similar to RAS-RELATED PROTEIN RAB-17.
BC000929 - Homo sapiens, hypothetical protein FLJ12538 similar to ras-related protein RAB17, clone IMAGE:3445550, mRNA, partial cds.
BC023661 - Homo sapiens RAB17, member RAS oncogene family, mRNA (cDNA clone IMAGE:4861590), partial cds.
BX647412 - Homo sapiens mRNA; cDNA DKFZp686B0936 (from clone DKFZp686B0936).
BC009827 - Homo sapiens RAB17, member RAS oncogene family, mRNA (cDNA clone IMAGE:3948020), complete cds.
BC050426 - Homo sapiens RAB17, member RAS oncogene family, mRNA (cDNA clone MGC:54136 IMAGE:5761178), complete cds.
AL136645 - Homo sapiens mRNA; cDNA DKFZp564M1541 (from clone DKFZp564M1541).
AK225423 - Homo sapiens mRNA for RAB17, member RAS oncogene family variant, clone: HRC09180.
JD298066 - Sequence 279090 from Patent EP1572962.
JD468654 - Sequence 449678 from Patent EP1572962.
JD473363 - Sequence 454387 from Patent EP1572962.
JD119722 - Sequence 100746 from Patent EP1572962.
JD251654 - Sequence 232678 from Patent EP1572962.
JD190158 - Sequence 171182 from Patent EP1572962.
JD221105 - Sequence 202129 from Patent EP1572962.
JD485931 - Sequence 466955 from Patent EP1572962.
JD498109 - Sequence 479133 from Patent EP1572962.
JD437988 - Sequence 419012 from Patent EP1572962.
JD526510 - Sequence 507534 from Patent EP1572962.
JD105530 - Sequence 86554 from Patent EP1572962.
JD389420 - Sequence 370444 from Patent EP1572962.
JD192244 - Sequence 173268 from Patent EP1572962.
JD334927 - Sequence 315951 from Patent EP1572962.
JD098259 - Sequence 79283 from Patent EP1572962.
JD391411 - Sequence 372435 from Patent EP1572962.
CR533454 - Homo sapiens full open reading frame cDNA clone RZPDo834A0217D for gene RAB17, RAB17, member RAS oncogene family; complete cds, incl. stopcodon.
JD537197 - Sequence 518221 from Patent EP1572962.
JD151207 - Sequence 132231 from Patent EP1572962.
JD243545 - Sequence 224569 from Patent EP1572962.
KJ903070 - Synthetic construct Homo sapiens clone ccsbBroadEn_12464 RAB17 gene, encodes complete protein.
KJ894544 - Synthetic construct Homo sapiens clone ccsbBroadEn_03938 RAB17 gene, encodes complete protein.
AB463205 - Synthetic construct DNA, clone: pF1KB8602, Homo sapiens RAB17 gene for RAB17, member RAS oncogene family, without stop codon, in Flexi system.
AM392800 - Synthetic construct Homo sapiens clone IMAGE:100002201 for hypothetical protein (RAB17 gene).
CR457282 - Homo sapiens full open reading frame cDNA clone RZPDo834E039D for gene RAB17, RAB17, member RAS oncogene family; complete cds, incl. stopcodon.
JD203225 - Sequence 184249 from Patent EP1572962.
JD528648 - Sequence 509672 from Patent EP1572962.
JD470349 - Sequence 451373 from Patent EP1572962.
JD478932 - Sequence 459956 from Patent EP1572962.
JD061207 - Sequence 42231 from Patent EP1572962.
JD533766 - Sequence 514790 from Patent EP1572962.
JD263303 - Sequence 244327 from Patent EP1572962.
JD333635 - Sequence 314659 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H0T7 (Reactome details) participates in the following event(s):

R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-8873719 RAB geranylgeranylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: NM_022449, NP_071894, Q53QV6, Q6IA73, Q9BVU1, Q9H0T7, Q9H9U9, RAB17_HUMAN
UCSC ID: uc002vwz.2
RefSeq Accession: NM_022449
Protein: Q9H0T7 (aka RAB17_HUMAN or RB17_HUMAN)
CCDS: CCDS2520.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_022449.3
exon count: 6CDS single in 3' UTR: no RNA size: 2018
ORF size: 639CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1289.50frame shift in genome: no % Coverage: 99.06
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.