Human Gene TFCP2L1 (uc002tmx.3) Description and Page Index
  Description: Homo sapiens transcription factor CP2-like 1 (TFCP2L1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:121,974,164-122,042,778 Size: 68,615 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr2:121,981,917-122,042,685 Size: 60,769 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:121,974,164-122,042,778)mRNA (may differ from genome)Protein (479 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TF2L1_HUMAN
DESCRIPTION: RecName: Full=Transcription factor CP2-like protein 1; AltName: Full=CP2-related transcriptional repressor 1; Short=CRTR-1; AltName: Full=Transcription factor LBP-9;
FUNCTION: Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.
SIMILARITY: Belongs to the grh/CP2 family. CP2 subfamily.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.54 RPKM in Minor Salivary Gland
Total median expression: 248.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.9093-0.537 Picture PostScript Text
3' UTR -2767.287753-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007604 - CP2
IPR013761 - SAM/pointed

Pfam Domains:
PF04516 - CP2 transcription factor

SCOP Domains:
47769 - SAM/Pointed domain

ModBase Predicted Comparative 3D Structure on Q9NZI6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003714 transcription corepressor activity
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0002070 epithelial cell maturation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006694 steroid biosynthetic process
GO:0007028 cytoplasm organization
GO:0007431 salivary gland development
GO:0007565 female pregnancy
GO:0008340 determination of adult lifespan
GO:0045927 positive regulation of growth

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC064698 - Homo sapiens transcription factor CP2-like 1, mRNA (cDNA clone MGC:71670 IMAGE:30347863), complete cds.
AL137740 - Homo sapiens mRNA; cDNA DKFZp564C0164 (from clone DKFZp564C0164).
AF198488 - Homo sapiens transcription factor LBP-9 (LBP-9) mRNA, complete cds.
EU446702 - Synthetic construct Homo sapiens clone IMAGE:100070037; IMAGE:100011911; FLH258253.01L transcription factor CP2-like 1 (TFCP2L1) gene, encodes complete protein.
BC020554 - Homo sapiens, clone IMAGE:3049181, mRNA.
JD535002 - Sequence 516026 from Patent EP1572962.
JD061403 - Sequence 42427 from Patent EP1572962.
JD511375 - Sequence 492399 from Patent EP1572962.
JD259614 - Sequence 240638 from Patent EP1572962.
JD177941 - Sequence 158965 from Patent EP1572962.
JD445907 - Sequence 426931 from Patent EP1572962.
JD487607 - Sequence 468631 from Patent EP1572962.
JD253678 - Sequence 234702 from Patent EP1572962.
JD271311 - Sequence 252335 from Patent EP1572962.
JD046108 - Sequence 27132 from Patent EP1572962.
JD565167 - Sequence 546191 from Patent EP1572962.
JD562609 - Sequence 543633 from Patent EP1572962.
JD159198 - Sequence 140222 from Patent EP1572962.
JD498480 - Sequence 479504 from Patent EP1572962.
JD160575 - Sequence 141599 from Patent EP1572962.
JD077280 - Sequence 58304 from Patent EP1572962.
JD216577 - Sequence 197601 from Patent EP1572962.
JD294418 - Sequence 275442 from Patent EP1572962.
JD273710 - Sequence 254734 from Patent EP1572962.
JD187619 - Sequence 168643 from Patent EP1572962.
JD533172 - Sequence 514196 from Patent EP1572962.
JD108819 - Sequence 89843 from Patent EP1572962.
JD538748 - Sequence 519772 from Patent EP1572962.
JD137349 - Sequence 118373 from Patent EP1572962.
JD050564 - Sequence 31588 from Patent EP1572962.
JD474166 - Sequence 455190 from Patent EP1572962.
JD267747 - Sequence 248771 from Patent EP1572962.
JD086485 - Sequence 67509 from Patent EP1572962.
JD187270 - Sequence 168294 from Patent EP1572962.
JD371122 - Sequence 352146 from Patent EP1572962.
JD473521 - Sequence 454545 from Patent EP1572962.
JD334857 - Sequence 315881 from Patent EP1572962.
JD383350 - Sequence 364374 from Patent EP1572962.
DQ579605 - Homo sapiens piRNA piR-47717, complete sequence.
JD280234 - Sequence 261258 from Patent EP1572962.
JD225809 - Sequence 206833 from Patent EP1572962.
JD483523 - Sequence 464547 from Patent EP1572962.
JD277884 - Sequence 258908 from Patent EP1572962.
JD441472 - Sequence 422496 from Patent EP1572962.
JD522385 - Sequence 503409 from Patent EP1572962.
JD556472 - Sequence 537496 from Patent EP1572962.
JD500548 - Sequence 481572 from Patent EP1572962.
JD558029 - Sequence 539053 from Patent EP1572962.
JD139152 - Sequence 120176 from Patent EP1572962.
JD122733 - Sequence 103757 from Patent EP1572962.
JD342657 - Sequence 323681 from Patent EP1572962.
JD293801 - Sequence 274825 from Patent EP1572962.
JD259975 - Sequence 240999 from Patent EP1572962.
JD345991 - Sequence 327015 from Patent EP1572962.
JD065435 - Sequence 46459 from Patent EP1572962.
JD223215 - Sequence 204239 from Patent EP1572962.
JD368992 - Sequence 350016 from Patent EP1572962.
JD307502 - Sequence 288526 from Patent EP1572962.
JD385629 - Sequence 366653 from Patent EP1572962.
JD229872 - Sequence 210896 from Patent EP1572962.
JD546333 - Sequence 527357 from Patent EP1572962.
JD422164 - Sequence 403188 from Patent EP1572962.
JD224731 - Sequence 205755 from Patent EP1572962.
JD161865 - Sequence 142889 from Patent EP1572962.
JD289598 - Sequence 270622 from Patent EP1572962.
JD354708 - Sequence 335732 from Patent EP1572962.
JD553197 - Sequence 534221 from Patent EP1572962.
JD261637 - Sequence 242661 from Patent EP1572962.
JD221267 - Sequence 202291 from Patent EP1572962.
JD426838 - Sequence 407862 from Patent EP1572962.
JD049071 - Sequence 30095 from Patent EP1572962.
JD510640 - Sequence 491664 from Patent EP1572962.
JD110852 - Sequence 91876 from Patent EP1572962.
JD411357 - Sequence 392381 from Patent EP1572962.
JD067367 - Sequence 48391 from Patent EP1572962.
JD449539 - Sequence 430563 from Patent EP1572962.
JD532983 - Sequence 514007 from Patent EP1572962.
JD165161 - Sequence 146185 from Patent EP1572962.
JD403460 - Sequence 384484 from Patent EP1572962.
JD288338 - Sequence 269362 from Patent EP1572962.
JD281147 - Sequence 262171 from Patent EP1572962.
JD363775 - Sequence 344799 from Patent EP1572962.
JD357525 - Sequence 338549 from Patent EP1572962.
JD556878 - Sequence 537902 from Patent EP1572962.
JD107804 - Sequence 88828 from Patent EP1572962.
JD208180 - Sequence 189204 from Patent EP1572962.
JD341582 - Sequence 322606 from Patent EP1572962.
DQ579237 - Homo sapiens piRNA piR-47349, complete sequence.
JD514581 - Sequence 495605 from Patent EP1572962.
JD417824 - Sequence 398848 from Patent EP1572962.
JD206832 - Sequence 187856 from Patent EP1572962.
JD296192 - Sequence 277216 from Patent EP1572962.
JD300297 - Sequence 281321 from Patent EP1572962.
JD332666 - Sequence 313690 from Patent EP1572962.
JD178796 - Sequence 159820 from Patent EP1572962.
JD093915 - Sequence 74939 from Patent EP1572962.
JD457906 - Sequence 438930 from Patent EP1572962.
AK311692 - Homo sapiens cDNA, FLJ18734.
JD212147 - Sequence 193171 from Patent EP1572962.
JD498731 - Sequence 479755 from Patent EP1572962.
JD235994 - Sequence 217018 from Patent EP1572962.
JD151028 - Sequence 132052 from Patent EP1572962.
JD226786 - Sequence 207810 from Patent EP1572962.
JD219375 - Sequence 200399 from Patent EP1572962.
JD497881 - Sequence 478905 from Patent EP1572962.
JD075443 - Sequence 56467 from Patent EP1572962.
DQ570682 - Homo sapiens piRNA piR-30794, complete sequence.
JD158574 - Sequence 139598 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CRTR1, LBP9, NM_014553, NP_055368, Q4ZG43, Q9NZI6, TF2L1_HUMAN
UCSC ID: uc002tmx.3
RefSeq Accession: NM_014553
Protein: Q9NZI6 (aka TF2L1_HUMAN)
CCDS: CCDS2134.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014553.2
exon count: 15CDS single in 3' UTR: no RNA size: 9306
ORF size: 1440CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3034.00frame shift in genome: no % Coverage: 99.79
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.