Human Gene KRTCAP3 (uc002rks.3) Description and Page Index
  Description: Homo sapiens keratinocyte associated protein 3 (KRTCAP3), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:27,665,233-27,667,164 Size: 1,932 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr2:27,665,280-27,666,923 Size: 1,644 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:27,665,233-27,667,164)mRNA (may differ from genome)Protein (240 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: KCP3_HUMAN
DESCRIPTION: RecName: Full=Keratinocyte-associated protein 3; Short=KCP-3;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in skin, pancreas and keratinocytes.
SIMILARITY: Belongs to the TMEM54 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.92 RPKM in Colon - Transverse
Total median expression: 297.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.6047-0.417 Picture PostScript Text
3' UTR -26.50117-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020977 - Beta-casein-like

Pfam Domains:
PF12304 - Beta-casein like protein

ModBase Predicted Comparative 3D Structure on Q53RY4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC101689 - Homo sapiens keratinocyte associated protein 3, mRNA (cDNA clone MGC:126738 IMAGE:8069195), complete cds.
BC101687 - Homo sapiens keratinocyte associated protein 3, mRNA (cDNA clone MGC:126736 IMAGE:8069193), complete cds.
BC143574 - Homo sapiens keratinocyte associated protein 3, mRNA (cDNA clone MGC:177102 IMAGE:9052085), complete cds.
AY157576 - Homo sapiens keratinocytes associated protein 3 (KCP3) mRNA, complete cds.
KJ895797 - Synthetic construct Homo sapiens clone ccsbBroadEn_05191 KRTCAP3 gene, encodes complete protein.
AY358993 - Homo sapiens clone DNA129535 MRV222 (UNQ3066) mRNA, complete cds.
JD067321 - Sequence 48345 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZL49, KCP3, KCP3_HUMAN, NM_173853, NP_776252, Q53RY4, Q6UW42, Q8IWS5, UNQ3066/PRO9898
UCSC ID: uc002rks.3
RefSeq Accession: NM_173853
Protein: Q53RY4 (aka KCP3_HUMAN)
CCDS: CCDS1754.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_173853.3
exon count: 7CDS single in 3' UTR: no RNA size: 906
ORF size: 723CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1646.00frame shift in genome: no % Coverage: 97.90
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.