Human Gene CEACAM1 (uc002otv.3) Description and Page Index
  Description: Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1), transcript variant 1, mRNA.
RefSeq Summary (NM_001712): This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010].
Transcript (Including UTRs)
   Position: hg19 chr19:43,011,458-43,032,661 Size: 21,204 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr19:43,013,261-43,032,526 Size: 19,266 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:43,011,458-43,032,661)mRNA (may differ from genome)Protein (526 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 1; AltName: Full=Biliary glycoprotein 1; Short=BGP-1; AltName: CD_antigen=CD66a; Flags: Precursor;
INTERACTION: Q16568:CARTPT; NbExp=3; IntAct=EBI-4314481, EBI-4314526; P40199:CEACAM6; NbExp=2; IntAct=EBI-4314481, EBI-4314501;
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Secreted.
SUBCELLULAR LOCATION: Isoform 3: Secreted.
SUBCELLULAR LOCATION: Isoform 4: Secreted.
SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 6: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 7: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of cell-cell contact.
SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SEQUENCE CAUTION: Sequence=AAA57141.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=SeattleSNPs; URL="";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CEACAM1
CDC HuGE Published Literature: CEACAM1

-  MalaCards Disease Associations
  MalaCards Gene Search: CEACAM1
Diseases sorted by gene-association score: colorectal cancer (3), microinvasive gastric cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 58.10 RPKM in Colon - Transverse
Total median expression: 258.77 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.40135-0.359 Picture PostScript Text
3' UTR -552.441803-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set
IPR013151 - Immunoglobulin

Pfam Domains:
PF00047 - Immunoglobulin domain
PF07679 - Immunoglobulin I-set domain
PF07686 - Immunoglobulin V-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P13688
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015125 bile acid transmembrane transporter activity
GO:0019900 kinase binding
GO:0019903 protein phosphatase binding
GO:0031005 filamin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046983 protein dimerization activity
GO:1990782 protein tyrosine kinase binding

Biological Process:
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001568 blood vessel development
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0006469 negative regulation of protein kinase activity
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007229 integrin-mediated signaling pathway
GO:0010594 regulation of endothelial cell migration
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0015721 bile acid and bile salt transport
GO:0016477 cell migration
GO:0030334 regulation of cell migration
GO:0030853 negative regulation of granulocyte differentiation
GO:0032692 negative regulation of interleukin-1 production
GO:0032869 cellular response to insulin stimulus
GO:0035726 common myeloid progenitor cell proliferation
GO:0038016 insulin receptor internalization
GO:0038158 granulocyte colony-stimulating factor signaling pathway
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0043116 negative regulation of vascular permeability
GO:0043312 neutrophil degranulation
GO:0043318 negative regulation of cytotoxic T cell degranulation
GO:0044319 wound healing, spreading of cells
GO:0045601 regulation of endothelial cell differentiation
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051055 negative regulation of lipid biosynthetic process
GO:0060312 regulation of blood vessel remodeling
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0090331 negative regulation of platelet aggregation
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:1901143 insulin catabolic process
GO:1903385 regulation of homophilic cell adhesion
GO:1903670 regulation of sprouting angiogenesis
GO:2000346 negative regulation of hepatocyte proliferation
GO:2001214 positive regulation of vasculogenesis

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030054 cell junction
GO:0030658 transport vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031528 microvillus membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0042101 T cell receptor complex

-  Descriptions from all associated GenBank mRNAs
  X14831 - Human mRNA for transmembrane carcinoembryonic antigen BGPb (formerly TM2-CEA).
X16354 - Human mRNA for transmembrane carcinoembryonic antigen BGPa (formerly TM1-CEA).
AL833584 - Homo sapiens mRNA; cDNA DKFZp686P1556 (from clone DKFZp686P1556).
JD297691 - Sequence 278715 from Patent EP1572962.
JD110327 - Sequence 91351 from Patent EP1572962.
JD240115 - Sequence 221139 from Patent EP1572962.
JD500768 - Sequence 481792 from Patent EP1572962.
JD342681 - Sequence 323705 from Patent EP1572962.
JD553530 - Sequence 534554 from Patent EP1572962.
JD449630 - Sequence 430654 from Patent EP1572962.
JD552640 - Sequence 533664 from Patent EP1572962.
JD226200 - Sequence 207224 from Patent EP1572962.
JD241869 - Sequence 222893 from Patent EP1572962.
JD496019 - Sequence 477043 from Patent EP1572962.
JD145483 - Sequence 126507 from Patent EP1572962.
JD323274 - Sequence 304298 from Patent EP1572962.
JD324594 - Sequence 305618 from Patent EP1572962.
JD236668 - Sequence 217692 from Patent EP1572962.
JD302586 - Sequence 283610 from Patent EP1572962.
JD303912 - Sequence 284936 from Patent EP1572962.
JD147114 - Sequence 128138 from Patent EP1572962.
JD258350 - Sequence 239374 from Patent EP1572962.
J03858 - Human biliary glycoprotein I (BGP I) mRNA, complete cds.
JD103851 - Sequence 84875 from Patent EP1572962.
JD394008 - Sequence 375032 from Patent EP1572962.
JD215021 - Sequence 196045 from Patent EP1572962.
JD066020 - Sequence 47044 from Patent EP1572962.
JD107914 - Sequence 88938 from Patent EP1572962.
JD039325 - Sequence 20349 from Patent EP1572962.
AY766113 - Homo sapiens putative carcinoembryonic antigen-related cell adhesion molecule 1 short form 3 (CEACAM1) mRNA, complete cds; alternatively spliced.
X16356 - Human mRNA for transmembrane carcinoembryonic antigen BGPC (part.) (formerly TM3-CEA).
BC024164 - Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), mRNA (cDNA clone IMAGE:3932285), partial cds.
D12502 - Homo sapiens BGP mRNA for biliary glycoprotein, complete cds.
BC014473 - Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein), mRNA (cDNA clone MGC:23120 IMAGE:4871488), complete cds.
M76742 - Homo sapiens alternatively spliced biliary glycoprotein (BGPa) mRNA, complete cds.
AK314211 - Homo sapiens cDNA, FLJ94942.
S71326 - BGPc=biliary glycoprotein adhesion molecule {alternatively spliced} [human, HT29 colon carcinoma cell line, mRNA Partial, 1473 nt].
M76743 - Homo sapiens alternatively spliced biliary glycoprotein (BGPa) mRNA, partial cds.
M76744 - Homo sapiens alternatively spliced biliary glycoprotein (BGP) mRNA, 3' end of cds.
HQ447271 - Synthetic construct Homo sapiens clone IMAGE:100070581; CCSB007678_02 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) gene, encodes complete protein.
KJ901302 - Synthetic construct Homo sapiens clone ccsbBroadEn_10696 CEACAM1 gene, encodes complete protein.
E03350 - cDNA sequence coding for human carcinoembryonic antigen W211.
E03352 - cDNA sequence coding for human carcinoembryonic antigen (W239).
D90311 - Homo sapiens BGPg mRNA for biliary glycoprotein, complete cds, clone: W211.
D90313 - Homo sapiens BGPi mRNA for biliary glycoprotein, complete cds, clone: W239.
M72238 - Human biliary glycoprotein mRNA, complete cds.
E03351 - cDNA sequence coding for human carcinoembryonic antigen (W233).
D90312 - Homo sapiens BGPh mRNA for biliary glycoprotein, complete cds, clone: W233.
M69176 - Human biliary glycoprotein mRNA, complete cds.
S74647 - carcinoembryonic antigen TMzCEA {5' region} [human, hepatoma Li-7A cells, mRNA Partial, 199 nt].
CU677011 - Synthetic construct Homo sapiens gateway clone IMAGE:100019544 5' read CEACAM1 mRNA.
JD488645 - Sequence 469669 from Patent EP1572962.
JD148848 - Sequence 129872 from Patent EP1572962.
JD253849 - Sequence 234873 from Patent EP1572962.
JD459304 - Sequence 440328 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P13688 (Reactome details) participates in the following event(s):

R-HSA-202717 Heterodimerization of CEACAMs
R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-6798747 Exocytosis of tertiary granule membrane proteins
R-HSA-8867135 CEACAM1,3,5,6 bind opa proteins
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation
R-HSA-109582 Hemostasis
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A6NE38, A8MY49, BGP, BGP1, CEAM1_HUMAN, NM_001712, NP_001703, O60430, P13688, Q069I7, Q13854, Q13857, Q13858, Q13859, Q13860, Q15600, Q15601, Q16170, Q5UB49, Q7KYP5, Q96CA7, Q9UQV9
UCSC ID: uc002otv.3
RefSeq Accession: NM_001712
Protein: P13688 (aka CEAM1_HUMAN or CEA1_HUMAN)
CCDS: CCDS12609.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001712.4
exon count: 9CDS single in 3' UTR: no RNA size: 3528
ORF size: 1581CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3274.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.