Human Gene SH2D3A (uc002mft.3) Description and Page Index
Description: Homo sapiens SH2 domain containing 3A (SH2D3A), mRNA.
Transcript (Including UTRs)
Position: hg19 chr19:6,752,173-6,767,523 Size: 15,351 Total Exon Count: 10 Strand: -
Position: hg19 chr19:6,752,604-6,763,759 Size: 11,156 Coding Exon Count: 9
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=SH2 domain-containing protein 3A; AltName: Full=Novel SH2-containing protein 1;
FUNCTION: May play a role in JNK activation. SUBUNIT: Interacts with BCAR1. TISSUE SPECIFICITY: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung. PTM: Phosphorylated on tyrosine. SIMILARITY: Contains 1 SH2 domain.
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR023578 - Ras_GEF_dom
IPR001895 - RasGRF_CDC25
IPR000980 - SH2
Pfam Domains: PF00017 - SH2 domain
SCOP Domains: 48366 - Ras GEF
55550 - SH2 domain
ModBase Predicted Comparative 3D Structure on Q9BRG2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AY358406 - Homo sapiens clone DNA30676 NSP1 (UNQ175) mRNA, complete cds. BC006281 - Homo sapiens SH2 domain containing 3A, mRNA (cDNA clone MGC:10535 IMAGE:3958342), complete cds. AF124249 - Homo sapiens SH2-containing protein Nsp1 mRNA, complete cds. AK292781 - Homo sapiens cDNA FLJ76466 complete cds, highly similar to Homo sapiens SH2 domain containing 3A (SH2D3A), mRNA. AK299406 - Homo sapiens cDNA FLJ54935 complete cds, highly similar to SH2 domain-containing protein 3A. JD482751 - Sequence 463775 from Patent EP1572962. JD108553 - Sequence 89577 from Patent EP1572962. JD104153 - Sequence 85177 from Patent EP1572962. JD383345 - Sequence 364369 from Patent EP1572962. JD511447 - Sequence 492471 from Patent EP1572962. JD286587 - Sequence 267611 from Patent EP1572962. JD319172 - Sequence 300196 from Patent EP1572962. JD511445 - Sequence 492469 from Patent EP1572962. JD286586 - Sequence 267610 from Patent EP1572962. JD533204 - Sequence 514228 from Patent EP1572962. JD101954 - Sequence 82978 from Patent EP1572962. JD370528 - Sequence 351552 from Patent EP1572962. AK290293 - Homo sapiens cDNA FLJ78700 complete cds, highly similar to Homo sapiens SH2 domain containing 3A, mRNA. AK225386 - Homo sapiens mRNA for SH2 domain containing 3A variant, clone: HRC03017. JD331319 - Sequence 312343 from Patent EP1572962. JD382704 - Sequence 363728 from Patent EP1572962. JD526746 - Sequence 507770 from Patent EP1572962. JD156105 - Sequence 137129 from Patent EP1572962. JD052991 - Sequence 34015 from Patent EP1572962. JD536544 - Sequence 517568 from Patent EP1572962. JD459805 - Sequence 440829 from Patent EP1572962. JD047933 - Sequence 28957 from Patent EP1572962. JD439587 - Sequence 420611 from Patent EP1572962. DQ892750 - Synthetic construct clone IMAGE:100005380; FLH189353.01X; RZPDo839E0374D SH2 domain containing 3A (SH2D3A) gene, encodes complete protein. DQ895997 - Synthetic construct Homo sapiens clone IMAGE:100010457; FLH189349.01L; RZPDo839E0364D SH2 domain containing 3A (SH2D3A) gene, encodes complete protein. AK310659 - Homo sapiens cDNA, FLJ17701. AK024368 - Homo sapiens cDNA FLJ14306 fis, clone PLACE3000124. JD192814 - Sequence 173838 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A8K9R6, NM_005490, NP_005481, NSP1, Q9BRG2, Q9Y2X4, SH23A_HUMAN, UNQ175/PRO201 UCSC ID: uc002mft.3 RefSeq Accession: NM_005490
(aka SH23A_HUMAN) Q9BRG2
Gene Model Information
10 CDS single in 3' UTR:
1731 CDS single in intron:
Alignment % ID:
3123.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.