Human Gene SH2D3A (uc002mft.3) Description and Page Index
  Description: Homo sapiens SH2 domain containing 3A (SH2D3A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:6,752,173-6,767,523 Size: 15,351 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr19:6,752,604-6,763,759 Size: 11,156 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:6,752,173-6,767,523)mRNA (may differ from genome)Protein (576 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=SH2 domain-containing protein 3A; AltName: Full=Novel SH2-containing protein 1;
FUNCTION: May play a role in JNK activation.
SUBUNIT: Interacts with BCAR1.
TISSUE SPECIFICITY: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.
PTM: Phosphorylated on tyrosine.
SIMILARITY: Contains 1 SH2 domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.93 RPKM in Esophagus - Mucosa
Total median expression: 211.08 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.60194-0.477 Picture PostScript Text
3' UTR -147.60431-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023578 - Ras_GEF_dom
IPR001895 - RasGRF_CDC25
IPR000980 - SH2

Pfam Domains:
PF00017 - SH2 domain

SCOP Domains:
48366 - Ras GEF
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q9BRG2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005070 SH3/SH2 adaptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Biological Process:
GO:0007254 JNK cascade
GO:0007264 small GTPase mediated signal transduction
GO:0009967 positive regulation of signal transduction

Cellular Component:
GO:0005622 intracellular

-  Descriptions from all associated GenBank mRNAs
  AY358406 - Homo sapiens clone DNA30676 NSP1 (UNQ175) mRNA, complete cds.
BC006281 - Homo sapiens SH2 domain containing 3A, mRNA (cDNA clone MGC:10535 IMAGE:3958342), complete cds.
AF124249 - Homo sapiens SH2-containing protein Nsp1 mRNA, complete cds.
AK292781 - Homo sapiens cDNA FLJ76466 complete cds, highly similar to Homo sapiens SH2 domain containing 3A (SH2D3A), mRNA.
AK299406 - Homo sapiens cDNA FLJ54935 complete cds, highly similar to SH2 domain-containing protein 3A.
JD482751 - Sequence 463775 from Patent EP1572962.
JD108553 - Sequence 89577 from Patent EP1572962.
JD104153 - Sequence 85177 from Patent EP1572962.
JD383345 - Sequence 364369 from Patent EP1572962.
JD511447 - Sequence 492471 from Patent EP1572962.
JD286587 - Sequence 267611 from Patent EP1572962.
JD319172 - Sequence 300196 from Patent EP1572962.
JD511445 - Sequence 492469 from Patent EP1572962.
JD286586 - Sequence 267610 from Patent EP1572962.
JD533204 - Sequence 514228 from Patent EP1572962.
JD101954 - Sequence 82978 from Patent EP1572962.
JD370528 - Sequence 351552 from Patent EP1572962.
AK290293 - Homo sapiens cDNA FLJ78700 complete cds, highly similar to Homo sapiens SH2 domain containing 3A, mRNA.
AK225386 - Homo sapiens mRNA for SH2 domain containing 3A variant, clone: HRC03017.
JD331319 - Sequence 312343 from Patent EP1572962.
JD382704 - Sequence 363728 from Patent EP1572962.
JD526746 - Sequence 507770 from Patent EP1572962.
JD156105 - Sequence 137129 from Patent EP1572962.
JD052991 - Sequence 34015 from Patent EP1572962.
JD536544 - Sequence 517568 from Patent EP1572962.
JD459805 - Sequence 440829 from Patent EP1572962.
JD047933 - Sequence 28957 from Patent EP1572962.
JD439587 - Sequence 420611 from Patent EP1572962.
DQ892750 - Synthetic construct clone IMAGE:100005380; FLH189353.01X; RZPDo839E0374D SH2 domain containing 3A (SH2D3A) gene, encodes complete protein.
DQ895997 - Synthetic construct Homo sapiens clone IMAGE:100010457; FLH189349.01L; RZPDo839E0364D SH2 domain containing 3A (SH2D3A) gene, encodes complete protein.
AK310659 - Homo sapiens cDNA, FLJ17701.
AK024368 - Homo sapiens cDNA FLJ14306 fis, clone PLACE3000124.
JD192814 - Sequence 173838 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9R6, NM_005490, NP_005481, NSP1, Q9BRG2, Q9Y2X4, SH23A_HUMAN, UNQ175/PRO201
UCSC ID: uc002mft.3
RefSeq Accession: NM_005490
Protein: Q9BRG2 (aka SH23A_HUMAN)
CCDS: CCDS12173.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_005490.2
exon count: 10CDS single in 3' UTR: no RNA size: 2376
ORF size: 1731CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3123.00frame shift in genome: no % Coverage: 99.16
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.