Human Gene STAP2 (uc002mac.3) Description and Page Index
Description: Homo sapiens signal transducing adaptor family member 2 (STAP2), transcript variant 1, mRNA. RefSeq Summary (NM_017720): This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:4,324,040-4,338,941 Size: 14,902 Total Exon Count: 13 Strand: - Coding Region Position: hg19 chr19:4,324,130-4,338,750 Size: 14,621 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UGK3-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BC000795 - Homo sapiens signal transducing adaptor family member 2, mRNA (cDNA clone MGC:4988 IMAGE:3451782), complete cds. AK000241 - Homo sapiens cDNA FLJ20234 fis, clone COLF5673. AK125774 - Homo sapiens cDNA FLJ43786 fis, clone TESTI2052693, highly similar to Brk kinase substrate. AJ245719 - Homo sapiens mRNA for brk kinase substrate (BKS gene). KJ899159 - Synthetic construct Homo sapiens clone ccsbBroadEn_08553 STAP2 gene, encodes complete protein. AB527779 - Synthetic construct DNA, clone: pF1KB5841, Homo sapiens STAP2 gene for signal transducing adaptor family member 2, without stop codon, in Flexi system. JD062290 - Sequence 43314 from Patent EP1572962. JD346665 - Sequence 327689 from Patent EP1572962. JD141270 - Sequence 122294 from Patent EP1572962. JD320764 - Sequence 301788 from Patent EP1572962. JD387368 - Sequence 368392 from Patent EP1572962.