Human Gene STAP2 (uc002mac.3) Description and Page Index
  Description: Homo sapiens signal transducing adaptor family member 2 (STAP2), transcript variant 1, mRNA.
RefSeq Summary (NM_017720): This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr19:4,324,040-4,338,941 Size: 14,902 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr19:4,324,130-4,338,750 Size: 14,621 Coding Exon Count: 13 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:4,324,040-4,338,941)mRNA (may differ from genome)Protein (449 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STAP2
CDC HuGE Published Literature: STAP2

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.48 RPKM in Colon - Transverse
Total median expression: 397.74 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.60191-0.453 Picture PostScript Text
3' UTR -28.3090-0.314 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
50729 - PH domain-like
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q9UGK3-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Descriptions from all associated GenBank mRNAs
  BC000795 - Homo sapiens signal transducing adaptor family member 2, mRNA (cDNA clone MGC:4988 IMAGE:3451782), complete cds.
AK000241 - Homo sapiens cDNA FLJ20234 fis, clone COLF5673.
AK125774 - Homo sapiens cDNA FLJ43786 fis, clone TESTI2052693, highly similar to Brk kinase substrate.
AJ245719 - Homo sapiens mRNA for brk kinase substrate (BKS gene).
KJ899159 - Synthetic construct Homo sapiens clone ccsbBroadEn_08553 STAP2 gene, encodes complete protein.
AB527779 - Synthetic construct DNA, clone: pF1KB5841, Homo sapiens STAP2 gene for signal transducing adaptor family member 2, without stop codon, in Flexi system.
JD062290 - Sequence 43314 from Patent EP1572962.
JD346665 - Sequence 327689 from Patent EP1572962.
JD141270 - Sequence 122294 from Patent EP1572962.
JD320764 - Sequence 301788 from Patent EP1572962.
JD387368 - Sequence 368392 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UGK3 (Reactome details) participates in the following event(s):

R-HSA-8848023 Activated PTK6 binds STAP2
R-HSA-8848077 PTK6 phosphorylates STAP2
R-HSA-8848087 STAP2 recruits STAT3 to PTK6
R-HSA-8848124 PTK6 phosphorylates STAT3
R-HSA-8849474 PTK6 Activates STAT3
R-HSA-8848021 Signaling by PTK6
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BKS, NM_017720, NP_060190, Q9UGK3-2
UCSC ID: uc002mac.3
RefSeq Accession: NM_017720
Protein: Q9UGK3-2, splice isoform of Q9UGK3 CCDS: CCDS12128.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_017720.2
exon count: 13CDS single in 3' UTR: no RNA size: 1557
ORF size: 1350CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1652.00frame shift in genome: no % Coverage: 98.72
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.