Human Gene GGT6 (uc002fyd.4) Description and Page Index
Description: Homo sapiens gamma-glutamyltransferase 6 (GGT6), transcript variant 1, mRNA. RefSeq Summary (NM_001122890): GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 188.8.131.52) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]. Transcript (Including UTRs) Position: hg19 chr17:4,460,222-4,463,876 Size: 3,655 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr17:4,461,310-4,463,816 Size: 2,507 Coding Exon Count: 4
ID:GGT6_HUMAN DESCRIPTION: RecName: Full=Gamma-glutamyltransferase 6; Short=GGT 6; EC=184.108.40.206; AltName: Full=Gamma-glutamyltranspeptidase 6; AltName: Full=Glutathione hydrolase 6; EC=220.127.116.11; Contains: RecName: Full=Gamma-glutamyltransferase 6 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 6 light chain; Flags: Precursor; FUNCTION: Cleaves glutathione conjugates (By similarity). CATALYTIC ACTIVITY: A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. CATALYTIC ACTIVITY: Glutathione + H(2)O = L-cysteinylglycine + L- glutamate. PATHWAY: Sulfur metabolism; glutathione metabolism. SUBUNIT: Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (By similarity). SIMILARITY: Belongs to the gamma-glutamyltransferase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P531
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.