Human Gene GGT6 (uc002fyd.4) Description and Page Index
  Description: Homo sapiens gamma-glutamyltransferase 6 (GGT6), transcript variant 1, mRNA.
RefSeq Summary (NM_001122890): GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008].
Transcript (Including UTRs)
   Position: hg19 chr17:4,460,222-4,463,876 Size: 3,655 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr17:4,461,310-4,463,816 Size: 2,507 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:4,460,222-4,463,876)mRNA (may differ from genome)Protein (493 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: GGT6_HUMAN
DESCRIPTION: RecName: Full=Gamma-glutamyltransferase 6; Short=GGT 6; EC=2.3.2.2; AltName: Full=Gamma-glutamyltranspeptidase 6; AltName: Full=Glutathione hydrolase 6; EC=3.4.19.13; Contains: RecName: Full=Gamma-glutamyltransferase 6 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 6 light chain; Flags: Precursor;
FUNCTION: Cleaves glutathione conjugates (By similarity).
CATALYTIC ACTIVITY: A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
CATALYTIC ACTIVITY: Glutathione + H(2)O = L-cysteinylglycine + L- glutamate.
PATHWAY: Sulfur metabolism; glutathione metabolism.
SUBUNIT: Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (By similarity).
SIMILARITY: Belongs to the gamma-glutamyltransferase family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.86 RPKM in Colon - Transverse
Total median expression: 218.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.9060-0.332 Picture PostScript Text
3' UTR -399.581088-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000101 - GGT_peptidase

Pfam Domains:
PF01019 - Gamma-glutamyltranspeptidase

ModBase Predicted Comparative 3D Structure on Q6P531
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016787 hydrolase activity
GO:0036374 glutathione hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006751 glutathione catabolic process
GO:0008150 biological_process
GO:1901750 leukotriene D4 biosynthetic process

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK129501 - Homo sapiens cDNA FLJ25990 fis, clone DMC02673.
AK298329 - Homo sapiens cDNA FLJ51026 complete cds.
AK074646 - Homo sapiens cDNA FLJ90165 fis, clone MAMMA1000106.
JD323781 - Sequence 304805 from Patent EP1572962.
JD116446 - Sequence 97470 from Patent EP1572962.
JD186317 - Sequence 167341 from Patent EP1572962.
JD166708 - Sequence 147732 from Patent EP1572962.
JD372315 - Sequence 353339 from Patent EP1572962.
JD449629 - Sequence 430653 from Patent EP1572962.
JD466196 - Sequence 447220 from Patent EP1572962.
JD244194 - Sequence 225218 from Patent EP1572962.
JD357329 - Sequence 338353 from Patent EP1572962.
BC063111 - Homo sapiens gamma-glutamyltransferase 6, mRNA (cDNA clone MGC:71892 IMAGE:4593403), complete cds.
JD139830 - Sequence 120854 from Patent EP1572962.
JD522769 - Sequence 503793 from Patent EP1572962.
JD096407 - Sequence 77431 from Patent EP1572962.
JD054996 - Sequence 36020 from Patent EP1572962.
JD041652 - Sequence 22676 from Patent EP1572962.
JD169526 - Sequence 150550 from Patent EP1572962.
JD529331 - Sequence 510355 from Patent EP1572962.
JD557435 - Sequence 538459 from Patent EP1572962.
JD430269 - Sequence 411293 from Patent EP1572962.
JD557436 - Sequence 538460 from Patent EP1572962.
JD430270 - Sequence 411294 from Patent EP1572962.
JD084386 - Sequence 65410 from Patent EP1572962.
JD169524 - Sequence 150548 from Patent EP1572962.
JD430267 - Sequence 411291 from Patent EP1572962.
AK296645 - Homo sapiens cDNA FLJ50980 complete cds.
JD522404 - Sequence 503428 from Patent EP1572962.
JD288969 - Sequence 269993 from Patent EP1572962.
JD421717 - Sequence 402741 from Patent EP1572962.
JD517319 - Sequence 498343 from Patent EP1572962.
JD366229 - Sequence 347253 from Patent EP1572962.
JD534736 - Sequence 515760 from Patent EP1572962.
JD155783 - Sequence 136807 from Patent EP1572962.
AK300648 - Homo sapiens cDNA FLJ51104 complete cds.
JD499744 - Sequence 480768 from Patent EP1572962.
JD187819 - Sequence 168843 from Patent EP1572962.
JD533047 - Sequence 514071 from Patent EP1572962.
JD472384 - Sequence 453408 from Patent EP1572962.
JD273704 - Sequence 254728 from Patent EP1572962.
JD234943 - Sequence 215967 from Patent EP1572962.
JD378295 - Sequence 359319 from Patent EP1572962.
JD052776 - Sequence 33800 from Patent EP1572962.
JD473619 - Sequence 454643 from Patent EP1572962.
JD274740 - Sequence 255764 from Patent EP1572962.
JD138845 - Sequence 119869 from Patent EP1572962.
JD151670 - Sequence 132694 from Patent EP1572962.
JD102142 - Sequence 83166 from Patent EP1572962.
JD131402 - Sequence 112426 from Patent EP1572962.
JD459801 - Sequence 440825 from Patent EP1572962.
JD283258 - Sequence 264282 from Patent EP1572962.
JD089409 - Sequence 70433 from Patent EP1572962.
JD243925 - Sequence 224949 from Patent EP1572962.
JD186284 - Sequence 167308 from Patent EP1572962.
JD475007 - Sequence 456031 from Patent EP1572962.
JD436769 - Sequence 417793 from Patent EP1572962.
CU687648 - Synthetic construct Homo sapiens gateway clone IMAGE:100023100 5' read GGT6 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00430 - Taurine and hypotaurine metabolism
hsa00450 - Selenoamino acid metabolism
hsa00460 - Cyanoamino acid metabolism
hsa00480 - Glutathione metabolism
hsa00590 - Arachidonic acid metabolism
hsa01100 - Metabolic pathways

BioCyc Knowledge Library
PWY-4041 - γ-glutamyl cycle

Reactome (by CSHL, EBI, and GO)

Protein Q6P531 (Reactome details) participates in the following event(s):

R-HSA-5433072 GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG
R-HSA-8943279 GGT dimers hydrolyse GSH
R-HSA-5423646 Aflatoxin activation and detoxification
R-HSA-174403 Glutathione synthesis and recycling
R-HSA-211859 Biological oxidations
R-HSA-156590 Glutathione conjugation
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds

-  Other Names for This Gene
  Alternate Gene Symbols: B4DUH4, GGT6_HUMAN, NM_001122890, NP_001116362, Q6P531, Q8NCM0
UCSC ID: uc002fyd.4
RefSeq Accession: NM_001122890
Protein: Q6P531 (aka GGT6_HUMAN)
CCDS: CCDS45582.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001122890.1
exon count: 4CDS single in 3' UTR: no RNA size: 2635
ORF size: 1482CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2337.00frame shift in genome: no % Coverage: 99.81
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.