Human Gene TMEM45B (uc001qfe.1) Description and Page Index
  Description: Homo sapiens transmembrane protein 45B (TMEM45B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:129,685,741-129,729,898 Size: 44,158 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr11:129,722,378-129,728,580 Size: 6,203 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:129,685,741-129,729,898)mRNA (may differ from genome)Protein (275 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 45B;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM45 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM45B
CDC HuGE Published Literature: TMEM45B

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.12 RPKM in Small Intestine - Terminal Ileum
Total median expression: 212.22 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.7061-0.487 Picture PostScript Text
3' UTR -397.681318-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006904 - DUF716_TMEM45

Pfam Domains:
PF04819 - Family of unknown function (DUF716)

ModBase Predicted Comparative 3D Structure on Q96B21
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK098106 - Homo sapiens cDNA FLJ40787 fis, clone TRACH2006866.
AK290283 - Homo sapiens cDNA FLJ78140 complete cds, highly similar to Homo sapiens transmembrane protein 45B (TMEM45B), mRNA.
AK292058 - Homo sapiens cDNA FLJ78145 complete cds, highly similar to Homo sapiens transmembrane protein 45B (TMEM45B), mRNA.
BC016153 - Homo sapiens transmembrane protein 45B, mRNA (cDNA clone MGC:13208 IMAGE:3841102), complete cds.
KJ895350 - Synthetic construct Homo sapiens clone ccsbBroadEn_04744 TMEM45B gene, encodes complete protein.
GQ129440 - Synthetic construct Homo sapiens clone HAIB:100068651; DKFZo004A1236 transmembrane protein 45B protein (TMEM45B) gene, partial cds.
GQ129439 - Synthetic construct Homo sapiens clone HAIB:100068555; DKFZo008A1235 transmembrane protein 45B protein (TMEM45B) gene, complete cds.
JD148945 - Sequence 129969 from Patent EP1572962.
JD094644 - Sequence 75668 from Patent EP1572962.
JD205963 - Sequence 186987 from Patent EP1572962.
JD347416 - Sequence 328440 from Patent EP1572962.
JD038747 - Sequence 19771 from Patent EP1572962.
JD171603 - Sequence 152627 from Patent EP1572962.
JD326297 - Sequence 307321 from Patent EP1572962.
JD534069 - Sequence 515093 from Patent EP1572962.
JD358614 - Sequence 339638 from Patent EP1572962.
JD037781 - Sequence 18805 from Patent EP1572962.
JD246356 - Sequence 227380 from Patent EP1572962.
JD099157 - Sequence 80181 from Patent EP1572962.
JD056268 - Sequence 37292 from Patent EP1572962.
JD476025 - Sequence 457049 from Patent EP1572962.
JD074906 - Sequence 55930 from Patent EP1572962.
JD452928 - Sequence 433952 from Patent EP1572962.
JD087525 - Sequence 68549 from Patent EP1572962.
JD529520 - Sequence 510544 from Patent EP1572962.
JD169833 - Sequence 150857 from Patent EP1572962.
JD306464 - Sequence 287488 from Patent EP1572962.
JD055343 - Sequence 36367 from Patent EP1572962.
JD444784 - Sequence 425808 from Patent EP1572962.
JD161780 - Sequence 142804 from Patent EP1572962.
JD263756 - Sequence 244780 from Patent EP1572962.
JD280087 - Sequence 261111 from Patent EP1572962.
JD331693 - Sequence 312717 from Patent EP1572962.
JD382925 - Sequence 363949 from Patent EP1572962.
JD040138 - Sequence 21162 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K2L8, NM_138788, NP_620143, Q96B21, TM45B_HUMAN
UCSC ID: uc001qfe.1
RefSeq Accession: NM_138788
Protein: Q96B21 (aka TM45B_HUMAN)
CCDS: CCDS8482.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_138788.3
exon count: 6CDS single in 3' UTR: no RNA size: 2207
ORF size: 828CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1856.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.