Human Gene ANXA11 (uc001kbt.1)
  Description: Homo sapiens annexin A11 (ANXA11), transcript variant a, mRNA.
RefSeq Summary (NM_001157): This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015].
Transcript (Including UTRs)
   Position: hg19 chr10:81,914,880-81,965,328 Size: 50,449 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr10:81,915,609-81,932,617 Size: 17,009 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:81,914,880-81,965,328)mRNA (may differ from genome)Protein (505 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ANX11_HUMAN
DESCRIPTION: RecName: Full=Annexin A11; AltName: Full=56 kDa autoantigen; AltName: Full=Annexin XI; AltName: Full=Annexin-11; AltName: Full=Calcyclin-associated annexin 50; Short=CAP-50;
FUNCTION: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
SUBUNIT: Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.
SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell- cycle dependent.
DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid.
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ANXA11
CDC HuGE Published Literature: ANXA11

-  MalaCards Disease Associations
  MalaCards Gene Search: ANXA11
Diseases sorted by gene-association score: anxa11-related amyotrophic lateral sclerosis* (100), amyotrophic lateral sclerosis 1* (67), papillary hidradenoma (16), hidradenoma (5), hypersensitivity reaction type iv disease (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.96 RPKM in Whole Blood
Total median expression: 1228.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.50238-0.506 Picture PostScript Text
3' UTR -209.03729-0.287 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001464 - Annexin
IPR018502 - Annexin_repeat
IPR018252 - Annexin_repeat_CS
IPR008157 - AnnexinXI

Pfam Domains:
PF00191 - Annexin

SCOP Domains:
47874 - Annexin

ModBase Predicted Comparative 3D Structure on P50995
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008429 phosphatidylethanolamine binding
GO:0023026 MHC class II protein complex binding
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding

Biological Process:
GO:0006909 phagocytosis
GO:0007049 cell cycle
GO:0032506 cytokinetic process
GO:0051301 cell division
GO:0051592 response to calcium ion

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0030496 midbody
GO:0042470 melanosome
GO:0042581 specific granule
GO:0042582 azurophil granule
GO:0045335 phagocytic vesicle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AJ278463 - Homo sapiens mRNA for annexin A11 (ANXA11 gene), isoform a.
AJ278464 - Homo sapiens mRNA for annexin A11 (ANXA11 gene), isoform b.
AJ278465 - Homo sapiens mRNA for annexin A11 (ANXA11 gene), isoform c.
LF384971 - JP 2014500723-A/192474: Polycomb-Associated Non-Coding RNAs.
AK056107 - Homo sapiens cDNA FLJ31545 fis, clone NT2RI2000932, highly similar to Annexin A11.
AK222918 - Homo sapiens mRNA for annexin A11 variant, clone: HRC06149.
AK000567 - Homo sapiens cDNA FLJ20560 fis, clone KAT11951, highly similar to L19605 Homo sapiens 56K autoantigen annexin XI gene mRNA.
AK300509 - Homo sapiens cDNA FLJ55482 complete cds, highly similar to Annexin A11.
AK126287 - Homo sapiens cDNA FLJ44306 fis, clone TRACH2025084, highly similar to Annexin A11.
BC007564 - Homo sapiens annexin A11, mRNA (cDNA clone MGC:15491 IMAGE:2989058), complete cds.
GQ891463 - Homo sapiens clone HEL-S-184 epididymis secretory sperm binding protein mRNA, complete cds.
L19605 - Homo sapiens 56K autoantigen annexin XI gene mRNA, complete cds.
AB209770 - Homo sapiens mRNA for annexin A11 variant protein.
AK301047 - Homo sapiens cDNA FLJ58379 complete cds, highly similar to Annexin A11.
AK298362 - Homo sapiens cDNA FLJ51518 complete cds, highly similar to Annexin A11.
KJ890679 - Synthetic construct Homo sapiens clone ccsbBroadEn_00073 ANXA11 gene, encodes complete protein.
KR710107 - Synthetic construct Homo sapiens clone CCSBHm_00009654 ANXA11 (ANXA11) mRNA, encodes complete protein.
BT019934 - Homo sapiens annexin A11 mRNA, complete cds.
DQ893503 - Synthetic construct clone IMAGE:100006133; FLH194707.01X; RZPDo839E0380D annexin A11 (ANXA11) gene, encodes complete protein.
DQ896481 - Synthetic construct Homo sapiens clone IMAGE:100010941; FLH194703.01L; RZPDo839E0370D annexin A11 (ANXA11) gene, encodes complete protein.
CR450323 - Homo sapiens full open reading frame cDNA clone RZPDo834G051D for gene ANXA11, annexin A11; complete cds; without stopcodon.
AB385060 - Synthetic construct DNA, clone: pF1KB5182, Homo sapiens ANXA11 gene for annexin A11, complete cds, without stop codon, in Flexi system.
MA620548 - JP 2018138019-A/192474: Polycomb-Associated Non-Coding RNAs.
JD066432 - Sequence 47456 from Patent EP1572962.
AL357617 - Homo sapiens EST from clone 898903, full insert.
JD530997 - Sequence 512021 from Patent EP1572962.
JD045388 - Sequence 26412 from Patent EP1572962.
JD399280 - Sequence 380304 from Patent EP1572962.
JD427166 - Sequence 408190 from Patent EP1572962.
JD527288 - Sequence 508312 from Patent EP1572962.
JD200600 - Sequence 181624 from Patent EP1572962.
JD086100 - Sequence 67124 from Patent EP1572962.
JD076139 - Sequence 57163 from Patent EP1572962.
JD063386 - Sequence 44410 from Patent EP1572962.
JD185001 - Sequence 166025 from Patent EP1572962.
JD271349 - Sequence 252373 from Patent EP1572962.
JD185620 - Sequence 166644 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANX11, ANX11_HUMAN, NM_001157, NP_665876, P50995
UCSC ID: uc001kbt.1
RefSeq Accession: NM_001157
Protein: P50995 (aka ANX11_HUMAN or ANXB_HUMAN)
CCDS: CCDS7364.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene ANXA11:
als-overview (Amyotrophic Lateral Sclerosis Overview)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001157.2
exon count: 15CDS single in 3' UTR: no RNA size: 2486
ORF size: 1518CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3235.00frame shift in genome: no % Coverage: 99.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 128# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.