Description: Homo sapiens guanylate binding protein 2, interferon-inducible (GBP2), mRNA. RefSeq Summary (NM_004120): This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chr1:89,573,310-89,591,799 Size: 18,490 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr1:89,573,858-89,587,649 Size: 13,792 Coding Exon Count: 10
ID:GBP2_HUMAN DESCRIPTION: RecName: Full=Interferon-induced guanylate-binding protein 2; AltName: Full=GTP-binding protein 2; Short=GBP-2; Short=HuGBP-2; AltName: Full=Guanine nucleotide-binding protein 2; Flags: Precursor; FUNCTION: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). SUBUNIT: Homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Golgi apparatus membrane; Lipid-anchor. INDUCTION: By IFNG/IFN-gamma during macrophage activation, and by TNF-alpha and IL-1beta. SIMILARITY: Belongs to the GBP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P32456
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary